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mTOR Signaling in Anti-cancer Therapy Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 742

Special Issue Editor


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Guest Editor
Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun, Gongju-si 32439, Chungcheongnam-do , Republic of Korea
Interests: anti-cancer; autophagy; apoptosis; flavonoids

Special Issue Information

Dear Colleagues,

The mechanistic target of the rapamycin (mTOR) pathway is the main signaling cascade activated in various cancer cells, and its activation can promote carcinogenesis. The mTOR signaling pathway not only regulates gene transcription and protein synthesis to regulate cell proliferation and immune cell differentiation but also plays an important role in cancer metabolism. The mTOR pathway is potentially associated with apoptosis and autophagy and plays a key role in cancer. As a result, the mTOR signaling pathway is a popular target in anti-cancer therapy research.

This Special Issue concentrates on the role of the mTOR signaling pathway in anti-cancer therapy research. The papers published here will certainly contribute to the ever-growing cancer research and provide a new insight into the anti-cancer mechanism.

Prof. Dr. Ji-Youn Jung
Guest Editor

Manuscript Submission Information

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Keywords

  • mTOR
  • cancer
  • apoptosis
  • autophagy
  • cancer metabolism

Published Papers (1 paper)

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Review

17 pages, 5932 KiB  
Review
Interplay between mTOR and Purine Metabolism Enzymes and Its Relevant Role in Cancer
by Simone Allegrini, Marcella Camici, Mercedes Garcia-Gil, Rossana Pesi and Maria Grazia Tozzi
Int. J. Mol. Sci. 2024, 25(12), 6735; https://doi.org/10.3390/ijms25126735 - 19 Jun 2024
Viewed by 470
Abstract
Tumor cells reprogram their metabolism to meet the increased demand for nucleotides and other molecules necessary for growth and proliferation. In fact, cancer cells are characterized by an increased “de novo” synthesis of purine nucleotides. Therefore, it is not surprising that specific enzymes [...] Read more.
Tumor cells reprogram their metabolism to meet the increased demand for nucleotides and other molecules necessary for growth and proliferation. In fact, cancer cells are characterized by an increased “de novo” synthesis of purine nucleotides. Therefore, it is not surprising that specific enzymes of purine metabolism are the targets of drugs as antineoplastic agents, and a better knowledge of the mechanisms underlying their regulation would be of great help in finding new therapeutic approaches. The mammalian target of the rapamycin (mTOR) signaling pathway, which is often activated in cancer cells, promotes anabolic processes and is a major regulator of cell growth and division. Among the numerous effects exerted by mTOR, noteworthy is its empowerment of the “de novo” synthesis of nucleotides, accomplished by supporting the formation of purinosomes, and by increasing the availability of necessary precursors, such as one-carbon formyl group, bicarbonate and 5-phosphoribosyl-1-pyrophosphate. In this review, we highlight the connection between purine and mitochondrial metabolism, and the bidirectional relation between mTOR signaling and purine synthesis pathways. Full article
(This article belongs to the Special Issue mTOR Signaling in Anti-cancer Therapy Research)
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