Molecular Mechanisms Associated to Systemic Lupus Erythematosus
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2828
Special Issue Editor
Interests: drug delivery systems; non-coding RNA; extracellular vesicles; exosomes; blood-urine-renal delivery; renal glomerular crosstalk; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease extremely heterogeneous with a wide spectrum of different combinations of clinical manifestations, accumulation of laboratory and immunological abnormalities, and a variable disease progression and outcome. The etiology and pathogenesis of SLE are accompanied by immune disorders including abnormal activation, proliferation, differentiation, and dysfunction of immune cells. Over-secretion of autoantibodies against several cellular compartments triggers cytokine production by innate immune cells and incite tissue and organ inflammation. Despite considerable progress regarding the knowledge of the SLE pathophysiology, patients suffer a deficient and late diagnosis that conditions the disease progression. Determining a SLE patient-tailored preventive strategy remains a crucial problem to be resolved. This special issue welcomes original research manuscripts investigating novel molecular biomarkers that regulate critical pathways in SLE-associated activity and renal damage progression, the most common and serious manifestation in SLE, or new molecular regulatory networks identified by biology system analysis; critical reviews that summarize recent advances in this field and provide a rationale for further research are also welcome.
Dr. Raquel Cortes Vergaz
Guest Editor
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Keywords
- systemic lupus erythematosus
- lupus nephritis
- molecular mechanisms
- next generation sequencing
- immune cells
- extracellular vesicles
- non-coding RNA
- biology system analysis
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