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Latest Advances in Reproduction Biology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1572

Special Issue Editor


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Guest Editor
Tissue Microenvironment (TME) Lab, Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
Interests: reproduction biology

Special Issue Information

Dear Colleagues,

In recent years there has been an increase in knowledge of the reproductive biology of different animal species, leading to an improvement in terms of production and preservation of endangered species. Reproductive biology involves the biological processes related to the production of gametes, fertilization, embryo implantation and fetal development. We are pleased to invite you to this Special Issue to publish research paper and review article covering the cellular and molecular biology of reproduction, learning about current progress in the approaches that will be the groundwork for the next generation of research in reproductive and developmental biology. The research topis may include (but are not limited to) gamete formation; early embryo development and pregnancy; in vitro models to mimic gamete formation and embryo development and implantation, progress in molecular markers associated with fertility, developmental processes such as cell differentiation and reproductive disorders, as well as designing breeding strategies; the genetic and genomic analysis of gametes and embryos, fertility preservation, oocyte and embryo culture, transcriptomics and epigenomics, and the improvement of reproductive efficiency methods.

We hope that this book provides important and novel knowledge in the field of biology of animal reproduction.

Dr. Clara Malo
Guest Editor

Manuscript Submission Information

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Keywords

  • gamete formation
  • fertilization
  • embryo formation
  • embryo implantation
  • fertility
  • infertility
  • molecular markers
  • reproductive biology

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Published Papers (2 papers)

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Research

12 pages, 1533 KiB  
Article
Oocyte Competence, Embryological Outcomes and miRNA Signature of Different Sized Follicles from Poor Responder Patients
by Roberto Yagüe-Serrano, Andrea Palomar, Alicia Quiñonero, Víctor Hugo Gómez, Maria José de los Santos, Carmen Vidal and Francisco Dominguez
Int. J. Mol. Sci. 2024, 25(19), 10237; https://doi.org/10.3390/ijms251910237 - 24 Sep 2024
Viewed by 498
Abstract
Poor ovarian response (POR) patients often face the risk of not having enough competent oocytes. Then, aspirating small follicles could serve as a strategy to increase their number. Many efforts have been addressed to associate follicular size with oocyte competence, but results are [...] Read more.
Poor ovarian response (POR) patients often face the risk of not having enough competent oocytes. Then, aspirating small follicles could serve as a strategy to increase their number. Many efforts have been addressed to associate follicular size with oocyte competence, but results are controversial. Therefore, our study aimed to evaluate oocyte maturation and developmental competence, along with a non-invasive oocyte-maturation-related miRNA signature in oocytes retrieved from both large and small follicles. A total of 178 follicles, from 31 POR patients, were aspirated and measured on the day of ovarian puncture. Follicular diameters, oocyte collection, oocyte maturation, fertilization, blastocysts, and good-quality blastocyst rates were recorded. Simultaneously, follicular fluids were collected to quantify their miRNA expression. The efficacy of oocyte retrieval along with oocyte maturation, fertilization, and blastulation rates tended to increase with follicular size, but few significant differences were found. Despite there being significantly more collected oocytes from follicles > 11.5 mm compared to follicles ≤ 11.5 mm (p < 0.05), oocytes from the latter were also mature, with no significant differences in the miRNA signature, but only those > 13.5 mm demonstrated developmental competence. In conclusion, 11.5 mm follicles can produce mature oocytes, but only those larger than 13.5 mm yielded transferable embryos. Full article
(This article belongs to the Special Issue Latest Advances in Reproduction Biology)
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14 pages, 1953 KiB  
Article
Navigating the Intersection of Glycemic Control and Fertility: A Network Perspective
by Carlo Di Carlo, Costanza Cimini, Ramses Belda-Perez, Luca Valbonetti, Nicola Bernabò and Barbara Barboni
Int. J. Mol. Sci. 2024, 25(18), 9967; https://doi.org/10.3390/ijms25189967 - 16 Sep 2024
Viewed by 603
Abstract
The rising incidence of metabolic diseases is linked to elevated blood glucose levels, contributing to conditions such as diabetes and promoting the accumulation of advanced glycation end products (AGEs). AGEs, formed by non-enzymatic reactions between sugars and proteins, build up in tissues and [...] Read more.
The rising incidence of metabolic diseases is linked to elevated blood glucose levels, contributing to conditions such as diabetes and promoting the accumulation of advanced glycation end products (AGEs). AGEs, formed by non-enzymatic reactions between sugars and proteins, build up in tissues and are implicated in various diseases. This article explores the relationship between glycemic control and AGE accumulation, focusing on fertility implications. A computational model using network theory was developed, featuring a molecular database and a network with 145 nodes and 262 links, categorized as a Barabasi–Albert scale-free network. Three main subsets of nodes emerged, centered on glycemic control, fertility, and immunity, with AGEs playing a critical role. The transient receptor potential vanilloid 1 (TRPV1), a receptor expressed in several tissues including sperm, was identified as a key hub, suggesting that the modulation of TRPV1 in sperm by AGEs may influence fertility. Additionally, a novel link between glycemic control and immunity was found, indicating that immune cells may play a role in endocytosing specific AGEs. This discovery underscores the complex interplay between glycemic control and immune function, with significant implications for metabolic, immune health, and fertility. Full article
(This article belongs to the Special Issue Latest Advances in Reproduction Biology)
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