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Molecular Insights into Zoonotic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 789

Special Issue Editor

Special Issue Information

Dear Colleagues,

Infectious diseases continue to ravage human lives, causing significant morbidity and mortality worldwide. Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) is believed to have been in existence for several thousand years. TB continues to cause 2 million deaths every year and 10 million new cases annually worldwide.

Zoonotic tuberculosis (TB) is a form of TB in people caused by Mycobacterium bovis, which belongs to the M. tb complex. It often affects sites other than the lungs (extrapulmonary), but in many cases, it is clinically indistinguishable from TB caused by M. tb. Within animal populations, M. bovis is the causative agent of bovine TB. It mainly affects cattle, which are the most important animal reservoir, and can become established in wildlife. The disease results in important economic losses and trade barriers with a major impact on the livelihoods of poor and marginalized communities.

M. marinum, an atypical mycobacterium and a causative agent of fish tank granuloma, is transmitted from fish to humans. The ongoing pandemic has resulted in the neglect of several infectious diseases including TB and malaria. As the world tries to emerge from the pandemic, it is important to ensure that the entire world has access to health care to prevent future pandemics.

This Special Issue is dedicated to molecular-level research on host-pathogen interactions, pathogenesis, and the mechanisms of acute and chronic infections, with a focus on zoonotic diseases. We encourage submissions that explore the molecular aspects of human-animal interactions and the transmission of bacteria and viruses from animals to humans.

We welcome articles on the most recent advances in the discovery of novel therapeutic compounds and repurposed drugs that can potentially be utilized against infectious agents.We also invite submissions on preclinical and clinical research findings obtained from mechanistic studies. Since IJMS is a journal of molecular science, purely clinical studies and epidemiology will not suitable. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Prof. Dr. Vishwanath Venketaraman
Guest Editor

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Keywords

  • mycobacterial diseases
  • bubonic and pneumonic plague
  • Q fever
  • cat scratch disease
  • Mediterranean fever
  • HIV
  • malaria
  • ADIS
  • SARS-CoV-2
  • adjunctive therapy
  • immune-enhancing agents
  • antimycobacterial compounds
  • host-directed therapies
  • pathogenesis
  • modulation of host immune responses

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Published Papers (1 paper)

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Research

10 pages, 626 KiB  
Article
Torque teno virus (TTV) Infection in Patients with Encephalitis
by Henryk Jurasz, Iwona Bukowska-Ośko, Małgorzata Rydzanicz, Marta Popiel, Tomasz Dzieciątkowski, Karolina Bakuła-Grządka, Marcin Paciorek, Michał Makowiecki, Andrzej Horban, Tomasz Laskus, Marek Radkowski and Karol Perlejewski
Int. J. Mol. Sci. 2024, 25(20), 11177; https://doi.org/10.3390/ijms252011177 - 17 Oct 2024
Viewed by 637
Abstract
Torque teno virus (TTV) is a ssDNA orphan virus belonging to the Anelloviridae family, but some recent studies suggested its possible involvement in central nervous system (CNS) pathology. We analyzed serum and cerebrospinal fluid samples (CSF) from 109 patients with encephalitis for TTV [...] Read more.
Torque teno virus (TTV) is a ssDNA orphan virus belonging to the Anelloviridae family, but some recent studies suggested its possible involvement in central nervous system (CNS) pathology. We analyzed serum and cerebrospinal fluid samples (CSF) from 109 patients with encephalitis for TTV infection using serological and molecular testing, virus quantitative measurement, and next-generation sequencing-based (NGS) phylogenetic analysis. TTV noncoding region (UTR) and/or open reading frame 1 (ORF-1) sequences were detected in serum of 86 (79%) patients and in nine (8%) patients in CSF. Five of the latter patients were coinfected with various entero- and herpesviruses. Anti-TTV-IgG were detected in 80 (73.4%) sera and in two (1.8%) CSF samples, while anti-TTV-IgM were present in three (2.8%) sera and in none of the CSFs. Phylogenic analysis of CSF-derived TTV ORF-1 sequences revealed the presence of three unique variants in one patient. TTV was quantified in five CSF-serum pairs: in two patients viral loads were similar, and in three serum TTV loads were approximately one log higher. Our results suggest at least an occasional replication of TTV in CNS. However, whether TTV could be the cause of encephalitis requires further studies. Full article
(This article belongs to the Special Issue Molecular Insights into Zoonotic Diseases)
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