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Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination against Parasitic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 910

Special Issue Editors


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Guest Editor
Department of Tropical Parasitology, Institute of Maritime and Tropical Medicine in Gdynia, Medical University of Gdansk, Powstania Styczniowego 9b, 81-519 Gdynia, Poland
Interests: native antigen; recombinant protein; recombinant chimeric or fusion protein; diagnostic; subunit vaccine; DNA vaccine; epidemiology; antibody; cytokine

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Guest Editor
Department of Tropical Parasitology, Institute of Maritime and Tropical Diseases, Medical University of Gdańsk, 80-210 Gdańsk, Poland
Interests: parasites of humans and animals; protozoan parasites; infectious diseases, water-borne, food-borne, airborne pathogens; health and water; public health; transmission routes; molecular diagnostics
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Special Issue Information

Dear Colleagues,

Recent years have shown that climate change, urbanization, human population growth, and its interference with the natural environment translate into incidences of parasitic diseases among intermediate and final hosts. Moreover, we observe that parasitic diseases that have so far been characteristic of tropical zones are more and more often detected in other parts of the globe, resulting from global warming and, consequently, the migration of parasitic disease vectors and their final hosts. Additionally, the very common and well-known parasite infections caused by others members of Apicomplexa, including Toxoplasma gondii, Neospora sp., or Plasmodium spp., still pose a significant threat to the health and even survival of their hosts. This constitutes a huge challenge for research centers searching for new and effective drugs and/or vaccines that could increase the effectiveness of combating and counteracting parasitosis.

The development of the techniques used in molecular biology, genetic engineering, biochemical research, pharmacology, etc., allows for the improvement of existing and the development of new diagnostic methods, as well as the design of effective strategies for the control and prevention of parasitic diseases.

The current Special Issue aims to provide a comprehensive platform for molecular research on parasitic diseases, with a particular emphasis on potential advancements in their diagnosis, prevention, and treatment.

This Special Issue is supervised by Dr. Bartłomiej Tomasz Ferra and Dr. Anna Lass, assisted by our Topical Advisory Panel Member Dr. Dandan Hu (Guangxi University).

Dr. Bartłomiej Tomasz Ferra
Dr. Anna Lass
Guest Editors

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Keywords

  • parasitoses
  • vaccines
  • diagnostic
  • epidemiology
  • prevention
  • antibodies
  • cytokines
  • immune system
  • treatment
  • native antigen
  • recombinant protein
  • chimeric recombinant protein
  • multiepitope recombinant protein
  • pharmaceutical analogues
  • PCR
  • molecular techniques

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Published Papers (1 paper)

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Research

20 pages, 8798 KiB  
Article
Toxoplasma gondii ROP5 Enhances Type I IFN Responses by Promoting Ubiquitination of STING
by Qi-Wang Jin, Ting Yu, Ming Pan, Yi-Min Fan, Ceng-Ceng Ge, Xiao-Bing He, Jing-Zhi Gong, Jian-Ping Tao, Bao-Quan Fu, Zhi-Zhong Jing and Si-Yang Huang
Int. J. Mol. Sci. 2024, 25(20), 11262; https://doi.org/10.3390/ijms252011262 - 19 Oct 2024
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Abstract
Toxoplasma gondii is a widely spread opportunistic pathogen that can infect nearly all warm-blooded vertebrates and cause serious toxoplasmosis in immunosuppressed animals and patients. However, the relationship between the host’s innate immune system and effector proteins is poorly understood, particularly with regard to [...] Read more.
Toxoplasma gondii is a widely spread opportunistic pathogen that can infect nearly all warm-blooded vertebrates and cause serious toxoplasmosis in immunosuppressed animals and patients. However, the relationship between the host’s innate immune system and effector proteins is poorly understood, particularly with regard to how effectors antagonize cGAS-STING signaling during T. gondii infection. In this study, the ROP5 from the PRU strain of T. gondii was found to promote cGAS-STING-mediated immune responses. Mechanistically, ROP5 interacted with STING through predicted domain 2 and modulated cGAS-STING signaling in a predicted domain 3-dependent manner. Additionally, ROP5 strengthened cGAS-STING signaling by enhancing the K63-linked ubiquitination of STING. Consistently, ROP5 deficient PRU (PRUΔROP5) induced fewer type I IFN-related immune responses and replicated faster than the parental strain in RAW264.7 cells. Taken together, this study provides new insights into the mechanism by which ROP5 regulates T. gondii infection and provides new clues for strategies to prevent and control toxoplasmosis. Full article
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