Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 272
Special Issue Editor
Interests: endothelial dysfunction; cerebrovascular disease; JAK-STAT; therapeutic ultrasound
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A Special Issue on the “Molecular Mechanisms of Endothelial Dysfunction” is being prepared for the journal IJMS. Endothelial cells form a monolayer lining the luminal surface of every blood vessel; however, these cells do much more than simply create a physical barrier between circulating blood and tissues. Endothelial cells are heterogeneous in nature, with characteristics depending on vessel size and organ, with highly specialized cells found in the brain and kidney. The endothelium is essential for vascular homeostasis, responding to chemical and physical stimuli in a paracrine, autocrine, and endocrine manner to maintain vasomotor and tissue homeostasis, producing a range of factors that regulate vascular tone, thrombosis, cellular adhesion, inflammation, and smooth muscle proliferation. A functional endothelium and vasculature are essential to tissue health and function.
When endothelial cells become dysfunctional, they lose their ability to maintain homeostasis and gain other properties leading to consequences for both the vessels and the organs they supply. Traditionally, endothelial dysfunction was described as an impaired ability to generate nitric oxide by the endothelium, leading to increased oxidative stress; however, additional markers are now also used depending on organ, such as barrier integrity for cerebrovascular endothelial cells. Endothelial dysfunction may occur as a consequence, as well as contribute to the pathogenesis of many diseases including atherosclerosis, hypertension, type II diabetes, small vessel disease, vascular dementia, Alzheimer’s disease, chronic kidney disease, and stroke, with emerging evidence suggesting that endothelial dysfunction also occurs in complications associated with COVID-19. Endothelial dysfunction is a complex process involving many signaling pathways, depending on organ, vessel size, and sex, among other factors.
The elucidation of molecular mechanisms involved in endothelial dysfunction is crucial for the development of efficient therapies to improve endothelial function and vascular homeostasis in disease. This Special Issue invites the submission of original research articles and reviews presenting current studies into the molecular processes in endothelial homeostasis and how perturbation of these leads to endothelial dysfunction.
Dr. Catherine Davis
Guest Editor
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Keywords
- vascular permeability
- atherosclerosis
- blood–brain barrier
- endothelial adhesion molecules
- vasodilation
- thrombosis
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Related Special Issues
- Molecular Mechanisms of Endothelial Dysfunction in International Journal of Molecular Sciences (10 articles)
- Molecular Mechanisms of Endothelial Dysfunction 2.0 in International Journal of Molecular Sciences (10 articles)
- Molecular Mechanisms of Endothelial Dysfunction 3.0 in International Journal of Molecular Sciences (12 articles)
