Biological Effects of Low-Dose and Low-Dose-Rate Ionizing Radiation Exposure 2.0

Dear Colleagues,

Evaluation of the health risks associated with exposures of humans to low-dose and low-dose-rate ionizing radiation is prone to uncertainties due to the lack of knowledge of molecular mechanisms that underlie long-term health effects. This Special Issue will highlight the latest research on cellular and molecular effects of low-dose and low-dose-rate ionizing radiation exposures, such as DNA damage and repair, signal transduction, translation regulation, epigenetic rearrangement, and how they convert to cancer and non-cancer disease. We therefore invite research articles presenting novel results, reviews, and/or perspectives addressing or systematizing pertaining knowledge in this area. The specific topics that can be covered include but are not limited to:

• Links between initial DNA damage and subsequent mutagenesis and carcinogenesis;
• Mechanisms of radioadaptive responses and hormetic effects;
• The effect of dose rate on a choice of a DNA damage response pathway;
• Molecular biomarkers of exposure and bioindicators of health risks;
• Molecular responses to internal vs. external irradiation; radionuclide-specific effects;
• Effects of chronic cosmic radiation exposures associated with long-term manned space missions;
• Advances in molecular epidemiology;
• Application of artificial intelligence/machine learning to decoding low-dose and low-dose-rate molecular mechanisms;
• Consolidation of the knowledge of molecular mechanisms within the concept of adverse outcome pathways.

We look forward to your valuable contributions.

Prof. Dr. Andreyan N. Osipov
Dr. Dmitry Klokov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.