New Insights into Ferroptosis Inhibitors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2313
Special Issue Editor
Interests: sigma receptors; ER stress; oxidative stress; oxytosis; ferroptosis; dopaminergic neurotoxins; neuroprotective compounds; apoptosis; Parkinson's disease; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ferroptosis (also termed oxytosis) is an iron-dependent cell death pathway distinct from apoptosis and other forms of cell death. The terms related to ferroptosis include system xc-, cysteine, glutathione, GPX4, lipid peroxidation, reactive oxygen species, ferrous ion, Fenton reaction, erastin, glutamate, and so on. Ferroptosis is strongly implicated in neurodegenerative diseases, cancers, and metabolic disorders. Therefore, specific inhibitors may have broad clinical applications and the development and clinical application of such agents require a more detailed understanding of anti-ferroptotic mechanisms; studies using various in vitro model of ferroptosis/oxytosis as well as in vivo experimental models are encouraged. With this Special Issue focused on “New Insights into Ferroptosis Inhibitors”, freely accessible online from all over the world, we would like to provide various aspects of our knowledge on the small neuroprotective molecules that are effective in preventing ferroptosis/oxytosis. We thus welcome any original research and review articles related to any of these aspects.
We look forward to reading your contributions.
Prof. Dr. Yoko Hirata
Guest Editor
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Keywords
- system xc-
- cysteine
- glutathione
- GPX4
- lipid peroxidation
- reactive oxygen species
- ferrous ion
- Fenton reaction
- erastin
- glutamate
