Osteoarthritis: From Molecular Mechanism to Novel Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 6859
Special Issue Editor
Interests: cartilage; stem cells; scaffold; growth factors; TKR; CAS; orthobiology; ACL; meniscus transplant
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Osteoarthritis (OA) is the most common form of joint disease that appears in more than 10% of the world population and affects almost everyone over 65. As a consequence of the increasing longevity and obesity Worldwide especially in Western Countries, the economic and social burden of OA is rapidly and dramatically increasing affecting the quality of life of affected individuals and imposing enormous diagnostic, treatment, sick leave, rehabilitation, and early retirement costs on healthcare systems.
OA is not just an articular cartilage disease; it can be considered an organ failure of the entire joint with other abnormalities, especially of the bones, ligaments, synovium, and joint capsule. Furthermore, OA is characterized by its extraordinary interpatient variability both clinically and structurally which increases the complexity of OA and the ongoing difficulties in therapies. And no specific diagnostic biomarkers have been identified for OA that can identify the disease at its earliest stages.
With substantial advances in molecular biology, genetics, genomics, and animal models of OA, OA has evolved into a disease in which systemic inflammation and the immune system significantly alter the disease, also classifying it as an inflammatory disease. Consequently, disease-modifying drugs for osteoarthritis (DMOADS) are rapidly being developed, with attention shifting to novel targets including transcription factors, growth factors, and receptors. This Special Issue aims to help foster the advancement of the field of OA research and to disseminate new discoveries and information related to OA diagnosis, and therapy.
Dr. Berardo Di Matteo
Guest Editor
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Keywords
- osteoarthritis
- joint inflammation
- cartilage and chondrocyte function
- cartilage regeneration and repair
- post-traumatic osteoarthritis
- synovium
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