Recent Developments in Omics Technologies Applied to Oncology Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 822
Special Issue Editor
Interests: cancer research; melanoma; personalized precision medicine; pathway-targeted drugs; bcl-2 family protein; cancer biomarkers; microRNA; proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Intra-tumour heterogeneity is likely to have implications for cancer therapeutics and biomarker discovery, particularly in the era of targeted treatment, and evidence for a relationship between intra-tumoural heterogeneity and clinical outcome is emerging. Moreover, the composition of the tumor microenvironment, including immune cells, stromal cells, blood vessels, and extracellular matrix, also has a role in tumor aggressiveness and response to therapy. In particular, immune cells in the tumor microenvironment are relevant in determining tumor growth and response to immunotherapy. Thus, there is a need to characterize intra-tumour heterogeneity. Various techniques have been developed to characterize tumor heterogeneity and immune infiltrate composition in recent years. This Special Issue will focus on recent developments in spatial analysis (also at single cell level) of genomic, transcriptomic, proteomic, or metabolomic information obtainable from samples (tissues or fluids) derived from cancer patients. Authors are encouraged to submit original research manuscripts but can also provide suggestions for review articles.
Suitable topics include, but are not limited to:
- Single‑cell genome sequencing;
- Single‑cell epigenome sequencing;
- Single‑cell CRISPR sequencing;
- Imaging mass cytometry;
- RNAscope;
- Digital spatial profiling;
- Multiplex IHC;
- Multiplex IF.
Dr. Simona D’Aguanno
Guest Editor
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Keywords
- single‑cell genome sequencing
- single‑cell epigenome sequencing
- single‑cell CRISPR sequencing
- imaging mass cytometry
- RNAscope
- digital spatial profiling
- multiplex IHC
- multiplex IF
- omics technologies
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