Recent Research in Gut Microbiota–Gut–Brain Axis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 4754
Special Issue Editor
Special Issue Information
Dear Colleagues,
The microbiome is a complex ecosystem consisting of viruses, bacteria, fungi, protozoa and archaea resides in the human digestive track, respiratory system, and on skin surfaces. Various factors can disrupt the abundance of microbiota and affect its diversity and function, including the environment and various external factors, such as lifestyle, stress, and medical interventions. With the development of sequencing and multi-omics analysis technology, researchers are carrying out extensive research to elucidate microbiota biology, and reveal their critical role in the pathophysiology of depression, sleep disorders, Alzheimer's disease, Parkinson's disease and other neuropsychiatric disorders.
The microbiota–gut–brain axis is an important pathway for central/peripheral interactions. Bidirectional communication between the brain and the gut can be achieved through metabolic/endocrine, immune, and neuronal pathways, and these pathways are highly complex and interconnected. The afferent vagus nerve can sense and recognize metabolic and immune activity through peripheral transmitters, hormones, fatty acids, and inflammatory factors. Physiological and pathological products in the gut can be transmitted to the brain through the intestinal and blood–brain barriers, providing another pathway of communication from the gut to the brain. Identifying the key mediators between the gut microbiome and the central nervous system and clarifying the precise mechanisms are important for developing novel approaches to treat the related disorders.
This Special Issue is aimed at publishing high-quality pre-clinical and clinical research exploring the compositional and functional (e.g., metabolite) changes in gut microbiota that are associated with the development of neuropsychiatric disorders, and investigating the novel molecular and cellular mediators for signaling across the microbiota–gut–brain axis in health and disease. A variety of formats of publications, including original research articles, reviews, meta-analyses, and case reports, are welcome.
Dr. Ying Han
Guest Editor
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Keywords
- microbiota
- dysbiosis
- microbiota–gut–brain axis
- short-chain fatty acid
- immune pathway
- vagus nerve
- neuropsychiatric disorders
- depression
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