Mitochondria: Transport of Metabolites Across Biological Membranes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 3602
Special Issue Editors
Interests: air pollution; heavy metals; human health
Special Issues, Collections and Topics in MDPI journals
Interests: bioenergetics; mitochondrial carriers; mutagenesis; drosophila melanogaster; mitochondrial diseases; mitochondrial dysfunction; apoptosis; ROS; antioxidant and anti-inflammatory activity; cancer metabolism; anticancer agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The transport of metabolites across biological membranes, especially those of mitochondria, plays a vital role in maintaining cellular functions and adaptability to different environmental conditions. Mitochondria are essential organelles and hubs for cellular bioenergetics, metabolism, signaling and apoptosis. The mitochondrial inner membrane acts as a selective permeability barrier, as it contains many specialized protein transport systems able to mediate the import and export of numerous metabolites and ions, thus regulating cell respiration, energy production and calcium homeostasis.
The voltage-dependent anion channel is a component of the outer mitochondrial membrane, allowing for the passive transport of hydrophilic molecules and is involved in many biological processes, including mitochondrial permeability, apoptosis, autophagy and ferroptosis. The mitochondrial permeability transition pore causes the flux of low-molecular-weight solutes across the inner mitochondrial membrane. The release of mitochondrial components into the cytosol signals mitochondrial stress and integrates cellular responses via different signaling networks, thus modulating mitophagy, apoptosis or necrosis.
This Special Issue focuses on understanding and targeting mitochondrial transport systems and processes involving mitochondrial permeability, including the development of new potential therapeutic strategies for various human-associated diseases.
Dr. Graziantonio Lauria
Dr. Rosita Curcio
Guest Editors
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Keywords
- mitochondria
- mitochondrial transporters
- mitochondrial metabolism
- transport proteins
- translocases carriers
- mitochondrial carriers
- mitochondrial diseases
- mitochondrial permeability
- apoptosis
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