Molecular Biology of Age-Related Macular Degeneration (AMD)

Dear Colleagues,

Age-related macular degeneration (AMD) is the main cause of blindness in the elderly in developed countries, and is an emerging health and social problem, as the number of individuals affected by AMD in 2020 is estimated to reach about 200 million. Therefore, AMD is an important element of the global issue of vision loss. Additionally, there is no efficient treatment in most AMD cases. AMD is a complex disease that associates with aging and several genetic and environmental risk factors. Cellular reaction to oxidative stress, senescence, autophagy, inflammatory response, and DNA damage reaction are frequently reported to be impaired in AMD, but causative relationships between AMD and these effects are not completely clear. Therefore, studies on the molecular mechanisms of AMD pathogenesis are justified and can bring results important regarding its biology and therapy.

This Special Issue welcomes both original papers and review articles addressing one or several of the above-mentioned issues, or of the topics mentioned in the keywords listed below.

Prof. Dr. Janusz Blasiak
Prof. Dr. Kai Kaarniranta
Guest Editors

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