Neurodegeneration: From Genetics to Molecules—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 August 2024) | Viewed by 993
Special Issue Editors
Interests: Alzheimer’s disease; WWOX; tumor suppressor; peptide drugs; cancer; cancer-induced neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Molecular alterations play crucial roles in the pathogenesis of Alzheimer’s disease (AD) and other types of neurodegeneration. In 2019, the National Institute of Aging (NIA) announced that in addition to 20 known genes, there are five newly discovered genes, namely IQCK, ACE, ADAM10, ADAMTS1 and WWOX, which are associated with AD [1]. The functions of these five genes in the pathogenesis of AD and other neurodegeneration are largely unknown. Without a doubt, the addition of these new genes may assist our perspectives and understanding of the pathogenesis of AD and other neurodegeneration. For example, newborns with WWOX gene deficiency suffer severe neural diseases such as severe early infantile WWOX-related epileptic encephalopathy (WOREE) [2], metabolic disorder and early death. Furthermore, the downregulation of brain WWOX is frequently associated with AD progression in patients [3].
In this call for research and review papers, the specific topic will focus on the genetic alterations in proteins that contribute to the pathogenesis of AD and other neurodegeneration. We welcome articles related, but not limited to (1) gene-based molecular pathways in neurodegeneration; (2) gene-based therapy for neurodegeneration; (3) promising therapeutic strategies for neurodegeneration; (4) innate immunity in neurodegeneration, (5) proteins in chronic inflammation causing neurodegeneration in the brain; and (6) altered protein/protein interaction and signaling during signaling for inducing neurodegeneration.
References:
- Nat Genet. 2019, 51, 414–430;
- Brain. 2021, 144, 3061–3077;
- Front Neurosci. 2018, 12, 563.
Dr. Nan-Shan Chang
Dr. Subbiah Pugazhenthi
Guest Editors
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Keywords
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