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Advances in Molecular Biology and Bionic Systems Based on Polymers and Nanomaterials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 1997

Special Issue Editor


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Guest Editor
1. Institute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119992 Moscow, Russia
2. Institute for Biomedical Systems, National Research University of Electronic Technology (MIET), 124498 Moscow, Russia
Interests: bionic technologies and engineering; biomedical; cardiopulmonary resuscitation

Special Issue Information

Dear Colleagues,

The incorporation of electronic components with biological cells to monitor, repair, and control human organs at the tissue and single-cell levels is currently considered one of the most important global issues. Since 1980, tissue engineering has aimed at creating artificial substitutes with biological functions using the basic techniques of engineering and life science principles to build, repair, and regenerate damaged tissues and organs.

Polymer materials are actively used in molecular biology and bionic systems as implants and smart polymer materials. Bioactive polymers are capable of new bone and soft tissue growth stimulation, which opens great possibilities for their applications as different types of implants and surgical fixation devices. Smart polymer materials can perform the functions of membranes for bioseparation and microfluidics, and they are actively used in drug delivery systems, biosensor design, and as artificial muscles in bionic systems.

In addition, clinical electrophysiology is currently considered a very important issue in the development of neural prosthetics such as cochlear and artificial retina implants and brain stimulation electrodes for the treatment of Parkinson’s disease, depression, etc. The development of advanced bioelectronic devices, which interface with both the peripheral and central nervous systems for regulating organ function, augmenting sensory perception, and controlling prosthetics, is considered an extremely important topic.

This Special Issue will present the latest developments in molecular biology and bionic systems based on polymers and nanomaterials, covering the following topics:

  • Smart polymer materials;
  • Polymer implants;
  • Biomedical electronics for clinical applications;
  • Carbon nanomaterials for bioelectronic devices and tissue engineering;
  • Molecular biology in tissue engineering.

It is our pleasure to invite you to submit your full research papers, communications, and reviews to this Special Issue, "Advances in Molecular Biology and Bionic Systems Based on Polymers and Nanomaterials".

Dr. Dmitry Telyshev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart polymers
  • actuators and sensors
  • carbon nanocerias as a bioelectronic device
  • molecular biology
  • implants
  • optoelectronics

Published Papers (1 paper)

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Research

17 pages, 6509 KiB  
Article
Mechanoregulation of Osteoclastogenesis-Inducing Potentials of Fibrosarcoma Cell Line by Substrate Stiffness
by Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Qu Pengyu, Tsuyoshi Kimura and Hiroshi Egusa
Int. J. Mol. Sci. 2023, 24(10), 8959; https://doi.org/10.3390/ijms24108959 - 18 May 2023
Cited by 1 | Viewed by 1656
Abstract
A micro-physiological system is generally fabricated using soft materials, such as polydimethylsiloxane silicone (PDMS), and seeks an inflammatory osteolysis model for osteoimmunological research as one of the development needs. Microenvironmental stiffness regulates various cellular functions via mechanotransduction. Controlling culture substrate stiffness may help [...] Read more.
A micro-physiological system is generally fabricated using soft materials, such as polydimethylsiloxane silicone (PDMS), and seeks an inflammatory osteolysis model for osteoimmunological research as one of the development needs. Microenvironmental stiffness regulates various cellular functions via mechanotransduction. Controlling culture substrate stiffness may help spatially coordinate the supply of osteoclastogenesis-inducing factors from immortalized cell lines, such as mouse fibrosarcoma L929 cells, within the system. Herein, we aimed to determine the effects of substrate stiffness on the osteoclastogenesis-inducing potential of L929 cells via cellular mechanotransduction. L929 cells showed increased expression of osteoclastogenesis-inducing factors when cultured on type I collagen-coated PDMS substrates with soft stiffness, approximating that of soft tissue sarcomas, regardless of the addition of lipopolysaccharide to augment proinflammatory reactions. Supernatants of L929 cells cultured on soft PDMS substrates promoted osteoclast differentiation of the mouse osteoclast precursor RAW 264.7 by stimulating the expression of osteoclastogenesis-related gene markers and tartrate-resistant acid phosphatase activity. The soft PDMS substrate inhibited the nuclear translocation of YES-associated proteins in L929 cells without reducing cell attachment. However, the hard PDMS substrate hardly affected the cellular response of the L929 cells. Our results showed that PDMS substrate stiffness tuned the osteoclastogenesis-inducing potential of L929 cells via cellular mechanotransduction. Full article
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