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Molecular Advances and Perspectives in Rheumatic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 365

Special Issue Editor


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Guest Editor
Paediatric Department, University of Chieti “G. D’Annunzio”, 66100 Chieti, Italy
Interests: juvenile idiopathic arthritis; hypersensitivity vasculitis; psoriatic arthritis; rheumatic fever

Special Issue Information

Dear Colleagues,

Recent advancements in molecular biology have significantly improved our understanding of rheumatic diseases, providing new perspectives on their diagnosis and treatment. This Special Issue aims to highlight the molecular mechanisms underlying rheumatic diseases and explore novel therapeutic approaches.

Rheumatic diseases encompass a wide range of autoimmune and inflammatory conditions affecting joints, muscles, and connective tissues. The complexity of these diseases requires a multidisciplinary approach to uncover the molecular pathways involved and to develop targeted therapies.

This Special Issue will highlight the latest research on molecular advances in rheumatic diseases, covering various aspects such as genetic predisposition, molecular signaling pathways, immune system dysregulation, and innovative therapeutic strategies. We invite original research articles and reviews that contribute to generating a deeper understanding of the molecular basis of rheumatic diseases and present new perspectives for their management.

Research topics may include, but are not limited to, the following:

  • Molecular and cellular mechanisms in rheumatic disease pathogenesis, including genetic and epigenetic factors.
  • Role of cytokines and other inflammatory mediators in rheumatic diseases.
  • Advances in molecular diagnostics and biomarkers for early detection and monitoring of disease progression.
  • Therapeutic applications of molecular biology, including biologics and small molecule inhibitors.
  • Emerging molecular targets for drug development in rheumatic diseases.
  • Impact of environmental and lifestyle factors on molecular mechanisms in rheumatic diseases.

Dr. Luciana Breda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rheumatic diseases
  • molecular biology
  • inflammatory pathways
  • cytokines
  • molecular diagnostics
  • biologics
  • drug development
  • genetic factors
  • epigenetics
  • environmental influences

Published Papers (1 paper)

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Review

15 pages, 600 KiB  
Review
The Diagnostic Role of Skin Manifestations in Rheumatic Diseases in Children: A Critical Review of Paediatric Vasculitis
by Armando Di Ludovico, Marta Rinaldi, Federico Lauriola, Francesca Ciarelli, Saverio La Bella, Giulio Gualdi, Francesco Chiarelli, Kathryn Bailey and Luciana Breda
Int. J. Mol. Sci. 2024, 25(13), 7323; https://doi.org/10.3390/ijms25137323 - 3 Jul 2024
Viewed by 278
Abstract
Skin lesions are frequently observed in children with rheumatic diseases, particularly in conditions such as IgA vasculitis (IgAV) and Kawasaki disease (KD). In paediatric vasculitis, the presence of skin lesions serves as an early indicator, emphasising the importance of timely diagnosis to prevent [...] Read more.
Skin lesions are frequently observed in children with rheumatic diseases, particularly in conditions such as IgA vasculitis (IgAV) and Kawasaki disease (KD). In paediatric vasculitis, the presence of skin lesions serves as an early indicator, emphasising the importance of timely diagnosis to prevent complications, such as cardiac or renal involvement. Conversely, autoinflammatory disorders like juvenile systemic lupus erythematosus (SLE) and juvenile dermatomyositis (DM) may manifest with cutaneous manifestations either at the onset of disease or during its progression. Identifying these skin lesions prior to the appearance of systemic symptoms offers an opportunity for early diagnosis and treatment, which has a positive influence on the outcomes. Additionally, it is noteworthy that specific rheumatological conditions, such as acute rheumatic fever (ARF) or oligoarticular or polyarticular forms of juvenile idiopathic arthritis (JIA), may exhibit occasional, but significant skin involvement, which is strongly correlated with an unfavourable prognosis. The assessment of skin is important in the holist approach to assessing patients for potentially systemic/multisystem disorder and helps distinguish discrete conditions. Full article
(This article belongs to the Special Issue Molecular Advances and Perspectives in Rheumatic Diseases)
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