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Bacterial Non-coding RNAs as Regulators of the Host-Pathogen Interaction during Infection

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (16 June 2023) | Viewed by 5347

Special Issue Editors

Prof. Dr. Arseny Kaprelyants

E-Mail Website
Guest Editor
Research Center of Biotechnology, Bach Institute of Biochemistry, 119071 Moscow, Russia
Interests: mycobacteria; resuscitation of dormant bacteria; antimicrobial compounds
Dr. Tatyana L. Azhikina

E-Mail Website
Guest Editor
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
Interests: transcriptomics; regulatory RNAs; non-coding transcriptome; host-pathogen interaction; infection; bacterial pathogenesis; epigenetics

Special Issue Information

Dear Colleagues,

Pathogenic bacteria have developed intricate strategies to survive in the infected host, which are implemented through transcriptional and post-transcriptional changes in a specific set of bacterial genes encoding virulence determinants. Bacterial non-coding RNAs and their targets are key components of a complex regulatory network that enables pathogens to reprogram their metabolism in order to adapt to and thrive in the hostile environment. In the past few years, a large number of small non-coding RNAs identified in infectious bacterial species have been implicated in the regulation of transcription, translation, and mRNA stability of effector proteins that manipulate the eukaryotic cell machinery for the benefit of the pathogen. Accumulating evidence suggests that small RNAs are key players in supporting pathogen persistence in the host by not only tailoring the bacterial transcriptome to environmental changes at different stages of infection but also by interacting with host transcriptional mechanisms to allow the pathogen to successfully evade host protective responses and establish productive intracellular infection.

Authors are invited to submit original research and review articles to this Special Issue, which features the latest achievements and current concepts regarding the role of bacterial non-coding RNAs as regulators of the infection process.

Prof. Dr. Arseny Kaprelyants
Dr. Tatyana L. Azhikina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-coding transcriptome
  • bacterial sRNAs
  • bacterial infection
  • regulation of expression
  • host–pathogen interaction
  • pathogenesis
  • virulence

Published Papers (2 papers)

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Research

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12 pages, 2001 KiB  
Article
Small RNA MTS1338 Configures a Stress Resistance Signature in Mycobacterium tuberculosis
by Billy A. Martini, Artem S. Grigorov, Yulia V. Skvortsova, Oksana S. Bychenko, Elena G. Salina and Tatyana L. Azhikina
Int. J. Mol. Sci. 2023, 24(9), 7928; https://doi.org/10.3390/ijms24097928 - 27 Apr 2023
Cited by 1 | Viewed by 1687
Abstract
In the course of evolution, Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, has developed sophisticated strategies to evade host immune response, including the synthesis of small non-coding RNAs (sRNAs), which regulate post-transcriptional pathways involved in the stress adaptation of mycobacteria. sRNA MTS1338 [...] Read more.
In the course of evolution, Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, has developed sophisticated strategies to evade host immune response, including the synthesis of small non-coding RNAs (sRNAs), which regulate post-transcriptional pathways involved in the stress adaptation of mycobacteria. sRNA MTS1338 is upregulated in Mtb during its infection of cultured macrophages and in the model of chronic tuberculosis, suggesting involvement in host–pathogen interactions. Here, we analyzed the role of MTS1338 in the Mtb response to macrophage-like stresses in vitro. The Mtb strain overexpressing MTS1338 demonstrated enhanced survival ability under low pH, nitrosative, and oxidative stress conditions simulating the antimicrobial environment inside macrophages. Transcriptomic analysis revealed that in MTS1338-overexpressing Mtb, the stress factors led to the activation of a number of transcriptional regulators, toxin–antitoxin modules, and stress chaperones, about half of which coincided with the genes induced in Mtb phagocytosed by macrophages. We determined the MTS1338 “core regulon”, consisting of 11 genes that were activated in all conditions under MTS1338 overexpression. Our findings indicate that MTS1338 is a stress-induced sRNA that promotes Mtb survival in macrophages by triggering adaptive transcriptional mechanisms in response to host antimicrobial defense reactions. Full article
(This article belongs to the Special Issue Bacterial Non-coding RNAs as Regulators of the Host-Pathogen Interaction during Infection)
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Review

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31 pages, 2278 KiB  
Review
Thirty Years of sRNA-Mediated Regulation in Staphylococcus aureus: From Initial Discoveries to In Vivo Biological Implications
by Guillaume Menard, Chloé Silard, Marie Suriray, Astrid Rouillon and Yoann Augagneur
Int. J. Mol. Sci. 2022, 23(13), 7346; https://doi.org/10.3390/ijms23137346 - 1 Jul 2022
Cited by 7 | Viewed by 3222
Abstract
Staphylococcus aureus is a widespread livestock and human pathogen that colonizes diverse microenvironments within its host. Its adaptation to the environmental conditions encountered within humans relies on coordinated gene expression. This requires a sophisticated regulatory network, among which regulatory RNAs (usually called sRNAs) [...] Read more.
Staphylococcus aureus is a widespread livestock and human pathogen that colonizes diverse microenvironments within its host. Its adaptation to the environmental conditions encountered within humans relies on coordinated gene expression. This requires a sophisticated regulatory network, among which regulatory RNAs (usually called sRNAs) have emerged as key players over the last 30 years. In S. aureus, sRNAs regulate target genes at the post-transcriptional level through base–pair interactions. The functional characterization of a subset revealed that they participate in all biological processes, including virulence, metabolic adaptation, and antibiotic resistance. In this review, we report 30 years of S. aureus sRNA studies, from their discovery to the in-depth characterizations of some of them. We also discuss their actual in vivo contribution, which is still lagging behind, and their place within the complex regulatory network. These shall be key aspects to consider in order to clearly uncover their in vivo biological functions. Full article
(This article belongs to the Special Issue Bacterial Non-coding RNAs as Regulators of the Host-Pathogen Interaction during Infection)
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