Molecular Research on Inflammatory Diseases of the Gut in Humans and Animals
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 2258
Special Issue Editor
Interests: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; Johne’s disease; gene regulation; biomarker
Special Issue Information
Dear Colleagues,
The digestive system development and gastrointestinal tract cell functions are ruled and determined by a multifaceted regime of genetic and epigenetic regulators, influenced by the environment during development. There is a genetic component in many gastrointestinal (GI) diseases (e.g., inflammatory bowel disease—IBD) in which conditions are inherited, and “marked” with epigenetic “signatures” under a given environment. Importantly, among the environmental challenges, the significant role of microbial intestine flora has been acknowledged in all aspects of pathobiology of the GI tract, for signs of malfunction from benign disease to malignancy.
The complex interactions that regulate mucosa immunity, GI homeostasis, normal intestine barrier function, defense against infections, macrophage/T-cell responses, and other associated mechanisms constitute not only a sophisticated immune system to protect the GI from infection, inflammation, and dysfunction, but also include a multidimensional network of molecular components that control normal cell function. Thus, either intestinal barrier dysfunction and inappropriate immune activation in IBD-related pathologies or infectious disease, namely Johne’s disease (or paratuberculosis), are considered debilitating diseases of the GI with high risk of morbidity in humans and animals, respectively. The genetic basis of complex symptom-based disorders, including symptoms from the gastrointestinal tract, is not fully understood in humans and animals. Beyond the anticipated, but inconclusive, zoonotic risk that infectious agents entail in these diseases, they are also known causes of human cancers such as colorectal cancer. This Special Issue welcomes original research, reviews, etc., at the molecular level, genome-wide scale, or in silico study contributions to report advances in the field. The goal is to encompass the genetic and epigenetic basis of physiological and disease activity of all elements of the GI tract, and to include lessons to be learned from human and animals alike. As a landmark of this multifaceted approach, this research will benefit from the lab to clinic, given that the discovery and validation of diagnostic and potentially therapeutic biomarkers for these unclear pathologies is paramount.
Dr. Kostas A. Triantaphyllopoulos
Guest Editor
Manuscript Submission Information
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Keywords
- gene
- epigenetic
- biomarker
- intestinal
- gut
- IBD
- mycobacterium avium
- Johne’s disease
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Title: The Gut Microbiome: A New Frontier in Neurological Disease Research
Author: Mohammad Sarif Mohiuddin
