Molecular and Cellular Aspects of Breast Cancer Metastasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 32
Special Issue Editor
2. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Interests: urinary biomarkers for early detection, prognostics, and prediction of the response to treatment of bladder cancer; the role of sphingolipid signaling cascade in cancers, such as colon, breast, and bladder
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Special Issue Information
Dear Colleagues,
Breast cancer is the most common cancer type in women in the US and worldwide. When breast cancer is detected early (i.e., SEER Stage Localized) or even when cancer cells have spread beyond the breast but are limited to the nearby lymph nodes (SEER Stage Regional), the 5 yr survival rates are 99% and 86%, respectively. However, when the disease reaches SEER Stage Distant or metastasis, the 5 yr survival rate is significantly reduced to 31%. The evidence strongly suggests the importance of finding the risk of distant recurrence prior to the clinical, radiographic, or pathological diagnosis of metastatic breast cancer. Currently, annual mammographies with or without ultrasound and MRI are recommended surveillance strategies for people who have been treated for breast cancer to detect decently sized recurrences; however, there are no data improving the overall survival by performing systemic imaging studies to identify distant metastasis. Thus, the prediction and earlier detection of breast cancer metastasis through surveillance, followed by earlier treatment, is prevailingly considered the best modality to address the dismal outcomes of advanced breast cancer. Considering all the above, this Special Issue is inviting research papers on the “Molecular and Cellular Aspects of Breast Cancer Metastasis”, including but not limited to prediction and early-detection biomarkers, new therapeutic targets, and first-in-class medications against breast cancer metastasis.
Dr. Hideki Furuya
Guest Editor
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Keywords
- precision medicine
- omics-based discovery research (genomics, proteomics, transcriptomics, and radiomics)
- non-invasive test
- liquid biopsy
- first-in-class medications
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