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Cancer Cell Plasticity for Reprogramming—from Mechanisms to Therapies
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Cancer Cell Plasticity for Reprogramming—from Mechanisms to Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 5268

Special Issue Editors

Dr. Moon Nyeo Park

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Guest Editor
Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, Republic of Korea
Interests: cancer; endocrinology; herbal medicine; pathology; cancer stem cell; cancer reprogramming; miRNA; alternative splicing factor; drug resistance; drug development; drug delivery system
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ji Hoon Jung

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Guest Editor
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
Interests: ferroptosis; p53; cancer metabolism; natural compound
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Cancer progresses through complex mechanisms, carried out by healthy adult stem cells and transformed stem cells, which are also widely known as cancer stem cells (CSC) or cancer-initiating cells. Adult stem cells are known to exist in the skin, mammary gland, viscera, prostate, brain, and hematopoietic system. It is known that various transcriptional changes in surrounding cells are controlled by changes in the characteristic phenotypes of cancer cell plasticity for reprogramming. Cancer cells have been found to reversely differentiate themselves by interactions with surrounding cells. Within this phenomenon, initiation and progression are performed and pre-mature transcription termination is defined. Cancer cells performing such switches were identified as immune cells, neurons, and oncogenic cells. Studies on cell biology and molecular biology, biochemical, structural biology, and biophysics are considered very important in understanding cancer reprogramming, in order to identify the molecular properties and functions of different proteins. Studies on the mechanisms of cancer reprogramming and novel mechanisms in protein network are welcome.

Dr. Moon Nyeo Park
Dr. Ji Hoon Jung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • cell stem cell
  • immune escape
  • PD-L1
  • EMT
  • MET
  • Metastasis
  • invasion
  • angiogenesis
  • mutation
  • pluripotenct circuity

Published Papers (2 papers)

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Review

24 pages, 1971 KiB  
Review
The Therapeutic Potential of a Strategy to Prevent Acute Myeloid Leukemia Stem Cell Reprogramming in Older Patients
by Moon Nyeo Park
Int. J. Mol. Sci. 2023, 24(15), 12037; https://doi.org/10.3390/ijms241512037 - 27 Jul 2023
Viewed by 2008
Abstract
Acute myeloid leukemia (AML) is the most common and incurable leukemia subtype. Despite extensive research into the disease’s intricate molecular mechanisms, effective treatments or expanded diagnostic or prognostic markers for AML have not yet been identified. The morphological, immunophenotypic, cytogenetic, biomolecular, and clinical [...] Read more.
Acute myeloid leukemia (AML) is the most common and incurable leukemia subtype. Despite extensive research into the disease’s intricate molecular mechanisms, effective treatments or expanded diagnostic or prognostic markers for AML have not yet been identified. The morphological, immunophenotypic, cytogenetic, biomolecular, and clinical characteristics of AML patients are extensive and complex. Leukemia stem cells (LSCs) consist of hematopoietic stem cells (HSCs) and cancer cells transformed by a complex, finely-tuned interaction that causes the complexity of AML. Microenvironmental regulation of LSCs dormancy and the diagnostic and therapeutic implications for identifying and targeting LSCs due to their significance in the pathogenesis of AML are discussed in this review. It is essential to perceive the relationship between the niche for LSCs and HSCs, which together cause the progression of AML. Notably, methylation is a well-known epigenetic change that is significant in AML, and our data also reveal that microRNAs are a unique factor for LSCs. Multiple-targeted approaches to reduce the risk of epigenetic factors, such as the administration of natural compounds for the elimination of local LSCs, may prevent potentially fatal relapses. Furthermore, the survival analysis of overlapping genes revealed that specific targets had significant effects on the survival and prognosis of patients. We predict that the multiple-targeted effects of herbal products on epigenetic modification are governed by different mechanisms in AML and could prevent potentially fatal relapses. Thus, these strategies can facilitate the incorporation of herbal medicine and natural compounds into the advanced drug discovery and development processes achievable with Network Pharmacology research. Full article
(This article belongs to the Special Issue Cancer Cell Plasticity for Reprogramming—from Mechanisms to Therapies)
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19 pages, 1845 KiB  
Review
The Roles of Exosomes in the Diagnose, Development and Therapeutic Resistance of Oral Squamous Cell Carcinoma
by Shan Shi, Zi-Li Yu and Jun Jia
Int. J. Mol. Sci. 2023, 24(3), 1968; https://doi.org/10.3390/ijms24031968 - 19 Jan 2023
Cited by 9 | Viewed by 2505
Abstract
Oral cancer is one of the most common cancers worldwide, of which more than half of patients are diagnosed at a locally advanced stage with poor prognosis due to recurrence, metastasis and resistant to treatment. Thus, it is imperative to further explore the [...] Read more.
Oral cancer is one of the most common cancers worldwide, of which more than half of patients are diagnosed at a locally advanced stage with poor prognosis due to recurrence, metastasis and resistant to treatment. Thus, it is imperative to further explore the potential mechanism of development and drug resistance of oral cancer. Exosomes are small endosome-derived lipid nanoparticles that are released by cells. Since the cargoes of exosomes were inherited from their donor cells, the cargo profiles of exosomes can well recapitulate that of their donor cells. This is the theoretical basis of exosome-based liquid biopsy, providing a tool for early diagnosis of oral cancer. As an important intracellular bioactive cargo delivery vector, exosomes play a critical role in the development of oral cancer by transferring their cargoes to receipt cells. More importantly, recent studies have revealed that exosomes could induce therapy-resistance in oral cancer through multiple ways, including exosome-mediated drug efflux. In this review, we summarize and compare the role of exosomes in the diagnosis, development and therapy-resistant of oral cancer. We also highlight the clinical application of exosomes, and discuss the advantages and challenges of exosomes serving as predictive biomarker, therapy target and therapy vector in oral cancer. Full article
(This article belongs to the Special Issue Cancer Cell Plasticity for Reprogramming—from Mechanisms to Therapies)
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