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Bioactive Compounds and Their Anticancer Effects

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 938

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Guest Editor
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
Interests: ferroptosis; p53; cancer metabolism; natural compound
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Special Issue Information

Dear Colleagues,

Bioactive compounds are naturally occurring substances that have the ability to interact with biological systems and produce a specific physiological effect. Many bioactive compounds have been studied for their potential anti-cancer effects.

Ferroptosis is a newly discovered form of apoptosis, which is an intracellular phenomenon that has received attention in recent cancer research. Ferroptosis refers to cell death via iron ion regulation, a programmed form of cell death caused by oxidative stress occurring inside the cell.

The main goal of this Special Issue is to study the mechanism of the possibility and effectiveness of new bioactive compounds as anti-cancer drugs through the ferroptosis signaling pathway.

Prof. Dr. Ji Hoon Jung
Guest Editor

Manuscript Submission Information

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Keywords

  • ferroptosis
  • natural compounds
  • bioactive compounds
  • p53
  • anti-cancer drugs

Published Papers (1 paper)

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Research

17 pages, 4507 KiB  
Article
Isolation, Identification, and Biological Activities of a New Chlorin e6 Derivative
by Rameshwar Prasad Pandit, Til Bahadur Thapa Magar, Rajeev Shrestha, Junmo Lim, Pallavi Gurung and Yong-Wan Kim
Int. J. Mol. Sci. 2024, 25(13), 7114; https://doi.org/10.3390/ijms25137114 - 28 Jun 2024
Viewed by 766
Abstract
Chlorin e6 is a well-known photosensitizer used in photodynamic diagnosis and therapy. A method for identifying and purifying a novel process-related impurity during the synthesis of chlorin e6 has been developed. Its structure was elucidated using NMR and HRMS. This new impurity is [...] Read more.
Chlorin e6 is a well-known photosensitizer used in photodynamic diagnosis and therapy. A method for identifying and purifying a novel process-related impurity during the synthesis of chlorin e6 has been developed. Its structure was elucidated using NMR and HRMS. This new impurity is formed from chlorophyll b rather than chlorophyll a, which is the source of chlorin e6. The intermediates formed during chlorin e6 synthesis were monitored using HPLC-mass spectrometry. This new impurity was identified as rhodin g7 71-ethyl ester, the structure of which remains unknown to date. The cytotoxic effects of this novel compound in both dark and light conditions were studied against five cancer cell lines (HT29, MIA-PaCa-2, PANC-1, AsPC-1, and B16F10) and a normal cell line (RAW264.7) and compared to those of chlorin e6. Upon irradiation using a laser at 0.5 J/cm2, rhodin g7 71-ethyl ester demonstrated higher cytotoxicity (2-fold) compared to chlorin e6 in the majority of the cancer cell lines. Furthermore, this new compound exhibited higher dark cytotoxicity compared to chlorin e6. Studies on singlet oxygen generation, the accumulation in highly vascular liver tissue, and the production of reactive oxygen species in MIA-PaCa-2 cancer cells via rhodin g7 71-ethyl ester correspond to its higher cytotoxicity as a newly developed photosensitizer. Therefore, rhodin g7 71-ethyl ester could be employed as an alternative or complementary agent to chlorin e6 in the photodynamic therapy for treating cancer cells. Full article
(This article belongs to the Special Issue Bioactive Compounds and Their Anticancer Effects)
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