Molecular Aspects of Cutaneous Squamous Cell Carcinoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 63256
Special Issue Editors
Interests: autoimmune bullous diseases; keratinocyte biology; neurobiology of the skin
Special Issues, Collections and Topics in MDPI journals
Interests: epidermal differentiation; skin barrier formation; wound healing; epidermal homeostasis; skin inflammation; mouse models
Interests: skin cancer; squamous cell carcinoma; psoriasis; epidermal homeostasis; keratinocyte stem cells; epidermal differentiation; skin inflammation; mouse models; zebrafish models; in vitro skin 3D model; skin tumor spheroids; next-generation sequencing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cutaneous Squamous Cell Carcinoma (cSCC) represents the second most frequent skin cancer and has recently showed a rapid increase in incidence worldwide. cSCC results from a multistep carcinogenesis process, ranging from actinic keratosis to metastatic cSCC, and derives from molecular alterations of those pathways that regulate the balance between proliferation, differentiation and apoptosis of epidermal cells. If identified early, it can be surgically treated, but it might be disfiguring and costly. On the other hand, if left untreated, cSCC can rapidly grow and often metastasizes. Hence, the identification of molecular biomarkers or altered gene networks will give a key mean through which the development of more effective and accessible therapies could be possible.
Therefore, this Special Issue will accept research articles and reviews recapitulating all the molecular aspects of the biology and pathology of cSCC in both human and animal models, along with a description of significative biomarkers, including transcriptional regulators of gene expression, mutations linked to severe prognosis, drug resistance, or molecular target therapies.
Prof. Dr. Carlo Pincelli
Dr. Maria I. Morasso
Dr. Elisabetta Palazzo
Guest Editors
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Keywords
- Actinic keratosis
- Squamous cell carcinoma
- Epidermal differentiation
- Hyperplasia
- Transcription factors
- Growth factor receptors
- Animal models
- Gene expression profiling
- Chemotherapy
- Molecular target therapy
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