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Role of Cytokines in Cancer Metastasis Studies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 2858

Special Issue Editor


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Guest Editor
1. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
2. School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei City 11031, Taiwan
Interests: pharmacology cancer; tumor metastasis to bone; cancer

Special Issue Information

Dear Colleagues,

Cytokines, mixture of multifunctional mediators, not only regulate cell-to-cell communication but also involve primary cancer colonizing at a secondary microenvironment and tumor-stroma crosstalk in cancer pathogenesis. The dual functionality of cytokines in cancer metastases may display both tumor-promoting and tumor-suppressive capabilities. Therefore, further exploration of the regulatory mechanisms that control the protumor and antitumor activities of cytokines in the setting of cancer metastases is warranted. This will allow for the design of therapeutic molecules that can effectively target the tumorigenic pathways in patients with cancer metastases. Early diagnosis is crucial for the optimal treatment of patients with cancer metastases. Therefore, understanding the molecular underpinnings that govern the cancer cell-cytokine interactions in the setting of cancer metastases is crucial for the development of more accurate diagnostics and efficacious therapies.

Dr. Ju-Fang Liu
Guest Editor

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Keywords

  • cytokines
  • cancer
  • metastasis
  • migration
  • EMT
  • cell signaling

Published Papers (1 paper)

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Review

14 pages, 1278 KiB  
Review
The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review
by Wojciech Łabędź, Anna Przybyla, Agnieszka Zimna, Mikołaj Dąbrowski and Łukasz Kubaszewski
Int. J. Mol. Sci. 2023, 24(4), 3785; https://doi.org/10.3390/ijms24043785 - 14 Feb 2023
Cited by 4 | Viewed by 2441
Abstract
Although many studies have investigated the role of cytokines in bone metastases, our knowledge of their function in spine metastasis is limited. Therefore, we performed a systematic review to map the available evidence on the involvement of cytokines in spine metastasis in solid [...] Read more.
Although many studies have investigated the role of cytokines in bone metastases, our knowledge of their function in spine metastasis is limited. Therefore, we performed a systematic review to map the available evidence on the involvement of cytokines in spine metastasis in solid tumors. A PubMed search identified 211 articles demonstrating a functional link between cytokines/cytokine receptors and bone metastases, including six articles confirming the role of cytokines/cytokine receptors in spine metastases. A total of 68 cytokines/cytokine receptors were identified to mediate bone metastases; 9 (mostly chemokines) played a role in spine metastases: CXC motif chemokine ligand (CXCL) 5, CXCL12, CXC motif chemokine receptor (CXCR) 4, CXCR6, interleukin (IL) 10 in prostate cancer, CX3C motif chemokine ligand (CX3CL) 1 and CX3C motif chemokine receptor (CX3CR) 1 in liver cancer, CC motif chemokine ligand (CCL) 2 in breast cancer, and transforming growth factor (TGF) β in skin cancer. Except for CXCR6, all cytokines/cytokine receptors were shown to operate in the spine, with CX3CL1, CX3CR1, IL10, CCL2, CXCL12, and CXCR4 mediating bone marrow colonization, CXCL5 and TGFβ promoting tumor cell proliferation, and TGFβ additionally driving bone remodeling. The number of cytokines/cytokine receptors confirmed to mediate spinal metastasis is low compared with the vast spectrum of cytokines/cytokine receptors participating in other parts of the skeleton. Therefore, further research is needed, including validation of the role of cytokines mediating metastases to other bones, to precisely address the unmet clinical need associated with spine metastases. Full article
(This article belongs to the Special Issue Role of Cytokines in Cancer Metastasis Studies)
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