The Role of DNA Damage in Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 January 2020)
Special Issue Editors
Interests: amyotrophiic lateral sclerosis; motor neuron disease; neurodegeneration; redox regulation; protein disulphide isomerase; DNA damage; ER stress; thiols
Interests: neurodegeneration, DNA damage, amyotrophic lateral sclerosis
Interests: neurodegeneration, DNA damage, amyotrophic lateral sclerosis, cancer
Special Issue Information
Dear Colleagues,
Genome fidelity is constantly targeted by both endogenous and exogenous factors. In response, the cell mounts the DNA damage response, a specific signaling pathway designed to detect and repair DNA damage, thus restoring cellular homeostasis. If unrepaired, damage to DNA can seriously compromise cellular viability and induce mutations. DNA damage also accumulates during the normal aging process. Defective DNA damage signaling mechanisms are well studied in proliferating cells, particularly in cancer, but their roles in post-mitotic neurons are not well understood. Increasing evidence suggests that DNA repair mechanisms are crucial for neuronal viability and that the consequences of genomic instability in the nervous system are severe. This is underscored by the numerous neurological conditions resulting from mutations in DNA repair proteins. In addition, a resilient DNA damage response is increasingly connected to age-related neurodegenerative disorders such as Amyotrophic Lateral Sclerosis and Alzheimer’s disease. In this volume, we aim to discuss recent advances linking neurodegenerative disorders to the DNA damage response.
Prof. Julie D. Atkin
Dr. Anna Konopka
Dr. Mariana Gabriela Brocardo
Guest Editors
Manuscript Submission Information
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Keywords
- DNA repair
- Neurodegeneration
- DNA damage response
- Amyotrophic lateral sclerosis
- Motor neuron disease
- Alzheimer's disease
- Neurons
