Molecular Mechanisms and Metabolic Pathway of Diabetic Retinopathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (1 February 2021) | Viewed by 3189
Special Issue Editor
Interests: AGEs formation; reactive oxidative stress; retinal endothelial cells; pericytes
Special Issue Information
Dear Colleagues,
Molecular mechanisms of diabetic retinopathy are suggested to underlie diabetes-induced complications. The pathogenesis of diabetic retinopathy has been shown to be related to increased polyol pathway flux, increased formation of advanced glycation end-products (AGEs), activation of the protein kinase C (PKC) pathway, and increased oxidative stress.
Retinal vascular occlusion causes the upregulation of such factors as insulin-like growth factor (IGF), stromal-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), angiopoietins (Ang-2), tumor necrosis factor (TNF), and basic fibroblast growth factor-2 (bFGF), which eventually contribute to the pathogenesis of diabetic retinopathy. The question of how growth factors play a pivotal role in diabetic retinopathy remains open to discussion.
Although alterations in metabolic pathways are suggested to occur in a hyperglycemic environment, the heightened production of reactive oxygen species (ROS) may interconnect the foregoing pathways. Nevertheless, recent advances in genetic technology have enabled us to show that a significant number of epigenetic alterations, including DNA methylation, histone modifications, and non-coding RNAs, participate in the development and progression of diabetic retinopathy.
This Special Issue of the International Journal of Molecular Science aims to provide an overview of the latest developments in our understanding of the mechanisms of diabetic retinopathy and their use in new therapeutic approaches to the treatment of various stages of diabetic retinopathy.
Dr. Young Sook Kim
Guest Editor
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Keywords
- diabetic retinopathy
- retinal microvascular abnormalities
- reactive oxygen species
- vascular cell death
- vascular occlusion
- epigenetic alterations.
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