Molecular Mechanisms and Metabolic Pathway of Diabetic Retinopathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (1 February 2021) | Viewed by 3189
Special Issue Editor
Interests: AGEs formation; reactive oxidative stress; retinal endothelial cells; pericytes
Special Issue Information
Dear Colleagues,
Molecular mechanisms of diabetic retinopathy are suggested to underlie diabetes-induced complications. The pathogenesis of diabetic retinopathy has been shown to be related to increased polyol pathway flux, increased formation of advanced glycation end-products (AGEs), activation of the protein kinase C (PKC) pathway, and increased oxidative stress.
Retinal vascular occlusion causes the upregulation of such factors as insulin-like growth factor (IGF), stromal-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), angiopoietins (Ang-2), tumor necrosis factor (TNF), and basic fibroblast growth factor-2 (bFGF), which eventually contribute to the pathogenesis of diabetic retinopathy. The question of how growth factors play a pivotal role in diabetic retinopathy remains open to discussion.
Although alterations in metabolic pathways are suggested to occur in a hyperglycemic environment, the heightened production of reactive oxygen species (ROS) may interconnect the foregoing pathways. Nevertheless, recent advances in genetic technology have enabled us to show that a significant number of epigenetic alterations, including DNA methylation, histone modifications, and non-coding RNAs, participate in the development and progression of diabetic retinopathy.
This Special Issue of the International Journal of Molecular Science aims to provide an overview of the latest developments in our understanding of the mechanisms of diabetic retinopathy and their use in new therapeutic approaches to the treatment of various stages of diabetic retinopathy.
Dr. Young Sook Kim
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetic retinopathy
- retinal microvascular abnormalities
- reactive oxygen species
- vascular cell death
- vascular occlusion
- epigenetic alterations.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.