Emerging Neuroprotective and Regenerative Strategies for the Treatment of Demyelinating Disorders of the Central Nervous
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 1339
Special Issue Editor
Interests: nervous system diseases; neuropharmacology; anatomy; biomolecular; musculoskeletal disorders; neuropathic pain
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Demyelinating disorders that specifically affect the brain and/or spine in the central nervous system (CNS) are common neurological conditions and can be separated into primary and secondary idiopathic inflammatory-demyelinating diseases (IIDDs). Both groups of IIDDs are characterised by damage to the myelin sheaths covering axons, with the main difference being that in secondary IIDDs, the aetiology is usually well defined (e.g., post-infectious, ischemic, metabolic, or toxic), so therapies targeting the underlying cause can (in most cases) successfully reverse disease progression. In contrast, there is no known cause for primary IIDDs, although growing evidence suggests the contribution of several risk factors (i.e., genetics, environment, life style, diet, etc.) in disease pathogenesis. To date, there is no definitive cure for primary IIDDs; however, there are several disease-modifying therapies able to alter disease progression in some patients and an increasing number of promising therapeutic strategies are currently under scrutiny in preclinical models and in clinical trials. Such emerging therapeutics primarily aim to increase neuroprotection, enhance nerve conduction and/or promote myelin regeneration.
The main scope of the Special Issue is to shed light on the most recent advances on such novel therapeutic strategies for IIDDs, as well as rare demyelinating conditions of the CNS. Special emphasis will be given to contributions focusing on the identification and preclinical validation of targets of potential clinical significance in demyelinating disorders of the CNS, as well as review articles providing updates on emerging treatment options for such devastating pathologies.
Dr. Alessandro Castorina
Guest Editor
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Keywords
- neuroprotection
- demyelinating disorders
- multiple sclerosis
- optic neuritis
- transverse myelitis
- Aicardi–Goutières syndrome
- acute disseminated encephalomyelitis
- neuromyelitis optica
- HTLV-I associated myelopathy
- Balo’s disease
- Schilder’s disease
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