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Molecular Innovations in Synthetic Organic Chemistry

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1232

Special Issue Editor


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Guest Editor
Medicines for All Institute, Virginia Commonwealth University, Richmond, VA 23284, USA
Interests: organic synthesis; process development; asymmetric synthesis; total synthesis; metal catalysis; green chemistry; medicinal chemistry

Special Issue Information

Dear Colleagues,

Synthetic organic chemistry is one of the arts of sciences to build chemical compounds ranging from small to complex molecules. Many bioactive molecules available in nature are either difficult to extract or are not sufficient in quantity for their applications. In this scenario, chemical synthesis has gained much more importance in recent times. The development of new synthetic compounds and innovations in their synthetic methods are highly desirable. The synthesis of organic compounds not only covers the synthesis of bioactive molecules, pharmaceuticals, or drug molecules but also covers a wide variety of agrochemicals and other useful functional materials.

We are pleased to invite you to submit research work achieved in the area of organic synthesis involving novel methodologies, molecules, and their applications. This Special Issue aims to collect original cutting-edge research work in the area of synthetic organic chemistry as scientific research articles, comprehensive reviews, communications, etc. The broader area of this Special Issue will be relevant to biological and molecular research focused on design, synthesis, characterization, and their applications.

The scope of this Special Issue is limited to areas such as metal-catalysis, asymmetric catalysis, metal-free reactions, green technologies, biocatalysis, organocatalysis, total synthesis, seminal synthesis, medicinal and pharmaceutical chemistry, etc.

We look forward to receiving your contributions.

Dr. Anand H. Shinde
Guest Editor

Manuscript Submission Information

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Keywords

  • organic synthesis
  • catalysis
  • material applications
  • bioactive molecules
  • active pharmaceutical ingredients
  • green chemistry

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Published Papers (1 paper)

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Research

22 pages, 5219 KiB  
Article
Study on Volatile Organic Compounds and Antioxidant Polyphenols in Cumin Produced in Xinjiang
by Minghao Sun, Xufang Lv, Xiuxiu Liu, Wenyu Chen, Xing Shen, Zhongping Chai and Maomao Zeng
Int. J. Mol. Sci. 2025, 26(6), 2628; https://doi.org/10.3390/ijms26062628 - 14 Mar 2025
Viewed by 329
Abstract
This article investigated the composition and content of volatile organic compounds (VOCs) in cumin from three Xinjiang origins (Hami, Turpan, and Hetian) at different processing temperatures. VOCs varied with temperature and origin, but alcohols and terpenes were predominant in all samples. Hetian cumin [...] Read more.
This article investigated the composition and content of volatile organic compounds (VOCs) in cumin from three Xinjiang origins (Hami, Turpan, and Hetian) at different processing temperatures. VOCs varied with temperature and origin, but alcohols and terpenes were predominant in all samples. Hetian cumin exhibited the highest VOC content and stability under specific treatments, divided into an ambient temperature treatment (AMB) and a 70 °C heat treatment. A cluster analysis revealed high similarity between replicates and significant differences among the samples. A Venn diagram comparison showed that 70 °C processing reduced the number of common VOCs among the three origins from 36 to 19, which is a decrease of 47.22%, indicating a significant impact of heating on cumin VOCs and possibly promoting the formation of new compounds. Finally, utilizing the varying abilities of different types of polyphenols to inhibit heterocyclic aromatic amines (HAAs), six polyphenolic compounds, identified as sesamin, 6-caffeoylsucrose, apigenin, eschweilenol C, kaempferol glucuronide, and luteolin, were preliminarily determined to play an active role in the β-carboline HAA simulation system. Full article
(This article belongs to the Special Issue Molecular Innovations in Synthetic Organic Chemistry)
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