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Redox Physiology in Biomedicine and Ecophysiology: The Influence of Various Substances on the Redox Regulation of Cell Metabolism, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 2285

Special Issue Editor

Dr. Slađan Pavlović

E-Mail Website
Guest Editor
Institute for Biological Research “Siniša Stanković”-National Institute of the Republic of Serbia, Belgrade, Serbia
Interests: redox physiology; antioxidative defense system; animal and human physiology; general and biomedical ecophysiology; metallomics; pathophysiology; toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in a Special Issue of MDPI’s International Journal of Molecular Sciences (ISSN 1422-0067) entitled: “Redox Physiology in Biomedicine and Ecophysology: Influence of Various Substances in Redox Regulation of Cell Metabolism 2.0”. It became clear that the modulation of the redox status can be the cause of many pathophysiological conditions in animals and humans. This is why this Special Issue covers a wide range of biomedical research with a special emphasis on results at the molecular level. We encourage authors to submit their manuscripts relating to: the impact of redox-active pollutants on the reproductive health of women and men; the connection between redox regulation of cellular redox status in COVID-19/post-COVID-19 patients; reactive species in redox signaling; redox-active natural products in diabetes; toxic trace elements in placental tissue, umbilical cord, and maternal blood in pregnant women with physiological pregnancies; influence of various xenobiotics on cellular redox status in aquatic organisms; and the influence of redox-active trace metals in physiological processes in normal and pathophysiological conditions.

Both Original research papers and Review articles are welcome.

Dr. Sladjan Z. Pavlović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox-signalling pathways
  • antioxidative and hypoglicemic effects of plant extracts
  • prooxidant/antioxidant status in the cells
  • redox active trace metals
  • reproductive health of women and men: infertility/sterility
  • xenobiotics in aquatic organims
  • essential trace elements and immunological parameters in COVID/post-COVID patients

Related Special Issue

Published Papers (3 papers)

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Research

15 pages, 6811 KiB  
Article
Effects of Liquid Fructose Supplementation and Chronic Unpredictable Stress on Uterine Contractile Activity in Nonpregnant Rats
by Zorana Oreščanin Dušić, Sanja Kovačević, Nataša Ristić, Danijela Vojnović Milutinović, Teodora Vidonja Uzelac, Duško Blagojević, Ana Djordjevic and Jelena Brkljačić
Int. J. Mol. Sci. 2024, 25(12), 6770; https://doi.org/10.3390/ijms25126770 - 20 Jun 2024
Viewed by 408
Abstract
Increased fructose consumption and chronic stress, the major characteristics of modern lifestyle, impact human health; however, the consequences of their combination on the uterus remain understudied. In this study, we investigated contractile activity, morphology, and intracellular activity of antioxidant enzymes in uteri from [...] Read more.
Increased fructose consumption and chronic stress, the major characteristics of modern lifestyle, impact human health; however, the consequences of their combination on the uterus remain understudied. In this study, we investigated contractile activity, morphology, and intracellular activity of antioxidant enzymes in uteri from virgin Wistar rats subjected to liquid fructose supplementation and/or unpredictable stress over 9 weeks. Contractile activity and uterine response to oxytocin or adrenaline were examined ex vivo using isolated bath chambers. Fructose supplementation, irrespective of stress, affected uterine morphology by increasing endometrium while decreasing myometrium volume density, attenuated uterine response to increasing doses of oxytocin, and increased glutathione peroxidase activity. Stress, irrespective of fructose, attenuated dose-dependent adrenaline-induced uterine relaxation. Stress, when applied solely, decreased mitochondrial superoxide dismutase activity. In the combined treatment, irregular estrous cycles and both reduced response to oxytocin and to adrenaline (as a consequence of fructose consumption and exposure to stress), along with fructose-related alteration of uterine morphology, were detected. In conclusion, fructose and stress affect uterine contractile activity, irrespective of each other, by inducing completely distinct responses in isolated uteri. In the combined treatment, the effects of both factors were evident, suggesting that the combination exerts more detrimental effects on the uterus than each factor individually. Full article
(This article belongs to the Special Issue Redox Physiology in Biomedicine and Ecophysiology: The Influence of Various Substances on the Redox Regulation of Cell Metabolism, 2nd Edition)
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18 pages, 2611 KiB  
Article
Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes
by Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović, Marko Miler, Tanja Grahovac, Zorana Oreščanin Dušić, Aleksandra Nikolić-Kokić and Duško Blagojević
Int. J. Mol. Sci. 2024, 25(12), 6527; https://doi.org/10.3390/ijms25126527 - 13 Jun 2024
Viewed by 629
Abstract
Ibogaine is an organic indole alkaloid that is used in alternative medicine to combat addiction. Numerous cases of life-threatening complications and sudden deaths associated with ibogaine use have been reported, and it has been hypothesized that the adverse effects are related to ibogaine’s [...] Read more.
Ibogaine is an organic indole alkaloid that is used in alternative medicine to combat addiction. Numerous cases of life-threatening complications and sudden deaths associated with ibogaine use have been reported, and it has been hypothesized that the adverse effects are related to ibogaine’s tendency to induce cardiac arrhythmias. Considering that the bioavailability of ibogaine and its primary metabolite noribogaine is two to three times higher in female rats than in male rats, we here investigated the effect of a single oral dose (1 or 20 mg/kg) of ibogaine on cardiac histopathology and oxidative/antioxidant balance. Our results show that ibogaine induced dose-dependent cardiotoxic necrosis 6 and 24 h after treatment and that this necrosis was not a consequence of inflammation. In addition, no consistent dose- and time-dependent changes in antioxidant defense or indicators of oxidative damage were observed. The results of this study may contribute to a better understanding of ibogaine-induced cardiotoxicity, which is one of the main side effects of ibogaine use in humans and is often fatal. Nevertheless, based on this experiment, it is not possible to draw a definitive conclusion regarding the role of redox processes or oxidative stress in the occurrence of cardiotoxic necrosis after ibogaine administration. Full article
(This article belongs to the Special Issue Redox Physiology in Biomedicine and Ecophysiology: The Influence of Various Substances on the Redox Regulation of Cell Metabolism, 2nd Edition)
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14 pages, 6006 KiB  
Article
Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis
by Lixing Cao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin and Hongbo Hu
Int. J. Mol. Sci. 2024, 25(5), 2458; https://doi.org/10.3390/ijms25052458 - 20 Feb 2024
Cited by 1 | Viewed by 817
Abstract
Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative [...] Read more.
Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative coumarin compound isolated from licorice that demonstrates various pharmacological activities. However, its potential for a protective effect against kidney injury remains unknown. We hypothesized that GC might be able to protect against AKI via suppression of ferroptosis. This hypothesis was tested in a cell-culture model of RSL3-induced nephrocyte ferroptosis and a mouse model of folic acid-induced AKI. The results showed that GC exerted a significant protective effect against nephrocyte ferroptosis in vitro and was effective against folic acid-induced AKI in vivo, where it was mechanistically associated with suppressing HO-1-mediated heme degradation. Collectively, the findings of the present study support the hypothesis that GC holds considerable potential to be developed as a novel agent for treating ferroptosis-related AKI. Full article
(This article belongs to the Special Issue Redox Physiology in Biomedicine and Ecophysiology: The Influence of Various Substances on the Redox Regulation of Cell Metabolism, 2nd Edition)
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