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Reproductive Endocrinology Research
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Reproductive Endocrinology Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2371

Special Issue Editor

Dr. Tsung-Hsien Lee

E-Mail Website
Guest Editor
Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung City 40201, Taiwan
Interests: reproductive endocrinology; infertility; pre-implantation genetic test for aneuploidy; sperm functional tests; assisted reproductive technology; endometriosis; embryo development; oxidative -reductive reaction; polycystic ovarian syndrome; epigenetics of gametes and embryos

Special Issue Information

Dear Colleagues,

As the Guest Editor for the upcoming Special Issue focusing on “Reproductive Endocrinology Research”, I am excited to welcome submissions that delve into the molecular aspects of reproductive endocrinology. This Special Issue aims to explore the cutting-edge molecular research being undertaken in reproductive health, fertility, and associated endocrine disorders. We are particularly interested in studies that advance our understanding of the molecular mechanisms underpinning reproductive processes, hormonal regulations, and their implications in clinical practice. Submissions may include, but are not limited to, research on hormonal signalling pathways, the genetic and epigenetic regulation of reproductive tissues, the molecular aspects of fertility and infertility, and the role of environmental factors in reproductive endocrinology. We welcome original research articles, comprehensive reviews, and case studies that contribute significant insights into the molecular dimensions of reproductive endocrinology. This Special Issue seeks to provide a platform for scientists and clinicians to share their latest findings and foster collaborative efforts towards advancing the field of reproductive health and medicine.

Dr. Tsung-Hsien Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular endocrinology
  • reproductive genetics
  • hormonal signaling pathways
  • fertility and infertility
  • epigenetics in reproduction
  • environmental impact on reproduction

Published Papers (2 papers)

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Research

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25 pages, 5678 KiB  
Article
The Impact of Ulmus macrocarpa Extracts on a Model of Sarcopenia-Induced C57BL/6 Mice
by Chan Ho Lee, Yeeun Kwon, Sunmin Park, TaeHee Kim, Min Seok Kim, Eun Ji Kim, Jae In Jung, Sangil Min, Kwang-Hyun Park, Jae Hun Jeong and Sun Eun Choi
Int. J. Mol. Sci. 2024, 25(11), 6197; https://doi.org/10.3390/ijms25116197 - 4 Jun 2024
Viewed by 627
Abstract
Aging leads to tissue and cellular changes, often driven by oxidative stress and inflammation, which contribute to age-related diseases. Our research focuses on harnessing the potent anti-inflammatory and antioxidant properties of Korean Ulmus macrocarpa Hance, a traditional herbal remedy, to address muscle loss [...] Read more.
Aging leads to tissue and cellular changes, often driven by oxidative stress and inflammation, which contribute to age-related diseases. Our research focuses on harnessing the potent anti-inflammatory and antioxidant properties of Korean Ulmus macrocarpa Hance, a traditional herbal remedy, to address muscle loss and atrophy. We evaluated the effects of Ulmus extract on various parameters in a muscle atrophy model, including weight, exercise performance, grip strength, body composition, muscle mass, and fiber characteristics. Additionally, we conducted Western blot and RT-PCR analyses to examine muscle protein regulation, apoptosis factors, inflammation, and antioxidants. In a dexamethasone-induced muscle atrophy model, Ulmus extract administration promoted genes related to muscle formation while reducing those associated with muscle atrophy. It also mitigated inflammation and boosted muscle antioxidants, indicating a potential improvement in muscle atrophy. These findings highlight the promise of Ulmus extract for developing pharmaceuticals and supplements to combat muscle loss and atrophy, paving the way for clinical applications. Full article
(This article belongs to the Special Issue Reproductive Endocrinology Research)
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Review

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25 pages, 1748 KiB  
Review
Hormone Regulation in Testicular Development and Function
by Lu Li, Wanqing Lin, Zhaoyang Wang, Rufei Huang, Huan Xia, Ziyi Li, Jingxian Deng, Tao Ye, Yadong Huang and Yan Yang
Int. J. Mol. Sci. 2024, 25(11), 5805; https://doi.org/10.3390/ijms25115805 - 26 May 2024
Viewed by 1404
Abstract
The testes serve as the primary source of androgens and the site of spermatogenesis, with their development and function governed by hormonal actions via endocrine and paracrine pathways. Male fertility hinges on the availability of testosterone, a cornerstone of spermatogenesis, while follicle-stimulating hormone [...] Read more.
The testes serve as the primary source of androgens and the site of spermatogenesis, with their development and function governed by hormonal actions via endocrine and paracrine pathways. Male fertility hinges on the availability of testosterone, a cornerstone of spermatogenesis, while follicle-stimulating hormone (FSH) signaling is indispensable for the proliferation, differentiation, and proper functioning of Sertoli and germ cells. This review covers the research on how androgens, FSH, and other hormones support processes crucial for male fertility in the testis and reproductive tract. These hormones are regulated by the hypothalamic–pituitary–gonad (HPG) axis, which is either quiescent or activated at different stages of the life course, and the regulation of the axis is crucial for the development and normal function of the male reproductive system. Hormonal imbalances, whether due to genetic predispositions or environmental influences, leading to hypogonadism or hypergonadism, can precipitate reproductive disorders. Investigating the regulatory network and molecular mechanisms involved in testicular development and spermatogenesis is instrumental in developing new therapeutic methods, drugs, and male hormonal contraceptives. Full article
(This article belongs to the Special Issue Reproductive Endocrinology Research)
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