Genetics of Lipids and Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 9201
Special Issue Editors
Interests: genetics; myocardiopathies; myocardial infarction; sudden death; microRNA; biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: genes; sudden death; electrophysiology; myocardial infarction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. One of the most important factors for CVD is lipid plasma concentration. In the last decade, lipid genetic studies have shown a wide range of influence in CVD: from monogenic hereditary dyslipidemias to multifactor genes. One the most important advances in lipidology was the description of low-density lipoprotein (LDL) receptor mutations and their association to familial hypercholesterolemias. However, over 250 genetic loci have been identified as potentially related to CVD—mainly in atherosclerosis, but lipid genetics may have a role in other cardiac pathologies such as atrial fibrillation and heart failure.
Multiple mechanisms have been suggested, including genes regulating arterial wall susceptibility to infiltration, transcytosis, retention, modification of LDL and genes acting outside this core mechanism pathway. Understanding the genetic landscape and regulation of lipids is mandatory in order to develop new strategies for prevention and treatment.
In this Special Issue we aim to collect high-quality research papers and updated reviews on various aspects of lipid genetics and CVD.
Dr. Manuel Hermida-Prieto
Dr. Lucía Núñez
Guest Editors
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Keywords
- GWAS
- mutation
- DNA sequencing
- atherosclerosis
- LDL
- familial hypercholesterolemia
- endothelium
- heart failure
- arrythmias
- lipids
- fatty acids
- HDL
- polygenic lipid disorders
- genetic risk score
- variant of lipoprotein metabolism
- dyslipidemia
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