Molecular Targeted Therapeutic Strategies for Glioblastoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 7012
Special Issue Editor
2 Division of Hematology-Oncology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
Interests: glioma; glioblastoma; medulloblastoma; brain cancer stem cells; kinase signaling; phosphorylation; kinase inhibitors; therapy resistance
Special Issue Information
Dear Colleagues,
This Special Issue is devoted to the diagnostic and therapeutic role of molecular markers and signaling pathways in glioblastoma (GBM). GBM, classified as WHO grade 4 glioma, is the most common malignant primary brain tumor and ranks among the most lethal of human cancers. Extensive efforts in the molecular characterization of GBM revealed remarkable intratumoral cellular heterogeneity and plasticity. GBM tumors contain diverse neoplastic populations among which glioma stem cells (GSCs) have been attributed key roles in plasticity and therapy resistance. Recent advances in molecular and genetic techniques have improved our understanding of GBM complexity and may help anticipate molecular adaptations and subtype transitions that promote disease recurrence and contribute to therapy resistance. This Special Issue will compile new data and concepts regarding targeted strategies for GBM that include, but are not limited to, targeting signaling pathways, immunotherapeutic approaches and strategies for drug delivery through the blood-brain barrier (BBB).
Dr. Frank Eckerdt
Guest Editor
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Keywords
- glioblastoma (GBM)
- glioma stem cells
- therapeutic target
- gBM subtypes
- tumor heterogeneity and plasticity
- therapy resistance
- tinase inhibitor
- signaling pathways
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