ijms-logo

Journal Browser

Journal Browser

Novel Insights in Cardiac Research: Mechanisms, Therapies, and Emerging Technologies

Special Issue Editor


E-Mail Website
Guest Editor
Laboratory of Cardiac Cellular Physiology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, I-20126 Milan, Italy
Interests: cardiac cellular physiology; arrhythmias; nanotechnology; optical stimulation; Ca2+ signalling; excitation-contraction coupling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to present the latest advancements in the field of cardiac cellular physiology, focusing on both foundational insights and innovative therapeutic approaches. We encourage contributions that explore recent breakthroughs in understanding the molecular and cellular mechanisms underlying cardiac function, arrhythmogenesis, and myocardial diseases. The issue will also highlight emerging strategies in therapeutic intervention, ranging from novel drug targets to cutting-edge technologies, including light-based approaches, gene editing, and personalized medicine.

More specifically, we invite original research articles, reviews, and perspectives that address, but are not limited to, the following topics:

  1. The mechanisms of arrhythmogenesis and its molecular pathways: investigating the molecular and cellular processes that drive arrhythmias and their underlying causes.
  2. The cellular and molecular basis of myocardial diseases: exploring the cellular alterations and molecular pathways involved in myocardial diseases such as cardiomyopathies and heart failure.
  3. Light-based approaches in cardiac research and therapy: harnessing optogenetics and light-sensitive technologies to study and treat cardiac dysfunctions.
  4. Gene editing technologies for precision cardiac therapies: exploring the use of gene editing tools to correct genetic mutations and offer personalized treatments for cardiovascular diseases.
  5. Advanced models for cardiac disease modeling and therapy: developing innovative in vitro, in vivo, and in silico models to better understand cardiac diseases and test potential therapeutic strategies.

Dr. Francesco Lodola
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac cellular physiology
  • gene therapy
  • arrhythmias
  • optical stimulation
  • precision therapy
  • cardiomyopathies
  • heart failure

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

27 pages, 2121 KiB  
Review
Cell Reprogramming, Transdifferentiation, and Dedifferentiation Approaches for Heart Repair
by Micael Almeida, José M. Inácio, Carlos M. Vital, Madalena R. Rodrigues, Beatriz C. Araújo and José A. Belo
Int. J. Mol. Sci. 2025, 26(7), 3063; https://doi.org/10.3390/ijms26073063 - 27 Mar 2025
Viewed by 136
Abstract
Cardiovascular disease (CVD) remains the leading cause of death globally, with myocardial infarction (MI) being a major contributor. The current therapeutic approaches are limited in effectively regenerating damaged cardiac tissue. Up-to-date strategies for heart regeneration/reconstitution aim at cardiac remodeling through repairing the damaged [...] Read more.
Cardiovascular disease (CVD) remains the leading cause of death globally, with myocardial infarction (MI) being a major contributor. The current therapeutic approaches are limited in effectively regenerating damaged cardiac tissue. Up-to-date strategies for heart regeneration/reconstitution aim at cardiac remodeling through repairing the damaged tissue with an external cell source or by stimulating the existing cells to proliferate and repopulate the compromised area. Cell reprogramming is addressed to this challenge as a promising solution, converting fibroblasts and other cell types into functional cardiomyocytes, either by reverting cells to a pluripotent state or by directly switching cell lineage. Several strategies such as gene editing and the application of miRNA and small molecules have been explored for their potential to enhance cardiac regeneration. Those strategies take advantage of cell plasticity by introducing reprogramming factors that regress cell maturity in vitro, allowing for their later differentiation and thus endorsing cell transplantation, or promote in situ cell proliferation, leveraged by scaffolds embedded with pro-regenerative factors promoting efficient heart restoration. Despite notable advancements, important challenges persist, including low reprogramming efficiency, cell maturation limitations, and safety concerns in clinical applications. Nonetheless, integrating these innovative approaches offers a promising alternative for restoring cardiac function and reducing the dependency on full heart transplants. Full article
Show Figures

Figure 1

Back to TopTop