Intratumor Heterogeneity and Therapy Resistance of Solid Tumors: Treacherous Apoptosis, Reversible Senescence, Genome Chaos, and More
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 244
Special Issue Editor
Interests: DNA damage response; p53 signaling; senescence; polyploidy; multinucleation; radioresistance; chemoresistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Single-cell biology has revealed that acquired resistance of cancer cells to therapeutic agents is multifactorial, with several unrelated mechanisms employed simultaneously by different subsets of cancer cells within the same tumor (intratumor heterogeneity). These include therapy-induced dormancy (durable proliferation arrest through polyploidy, multinucleation, and other manifestations of genome chaos), oncogenic caspase-3 activation (treacherous apoptosis), anastasis (a cell recovery phenomenon that rescues cancer cells from the brink of apoptotic and other modes of cell death), and cell fusion. The wild-type p53 and its downstream effector p21WAF1 also contribute to intratumor heterogeneity by activating transient cell cycle checkpoints to promote DNA repair, downregulating apoptotic cell death, and triggering a reversible proliferation arrest through premature senescence.
The purpose of this Special Issue is to provide a comprehensive update on the growing complexity of molecular and cellular responses to anticancer agents. Reviews and original research articles that utilize single cell biology to study the long-term fate of solid tumors/tumor-derived cell lines following treatment with anticancer agents are particularly welcomed.
Prof. Dr. Razmik Mirzayans
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- intratumor heterogeneity
- p53 signaling
- cell fusion
- reversible senescence
- anastasis
- oncogenic caspse-3
- chromothripsis (genome chaos)
- polyploid giant cancer cells (PGCCS)
- atavistic basis of therapy resistance
- cancer cell dormancy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.