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Cardiovascular Disease: Molecular Basis, Potential Therapeutic Targets and Translational Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 2486

Special Issue Editors


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Guest Editor
1. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania
2. Department of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
Interests: vascular surgery; acute limb ischemia; vascular access; carotid endarterectomy; peripheral arterial disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Clinical Sciences Malmö, Lund University, 21428 Malmö, Sweden
Interests: cardiovascular research; cardiac inflammation; innate immunity; cardiology; atherosclerosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
2. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Interests: vascular surgery; arteriovenous fistula; AVF; artery; vein; varicose veins; AAA; abdominal aortic aneurysms; carotid disease; endarterectomy; peripheral arterial disease; PAD; acute limb ischemia; critical limb ischemia; revascularization; revascularization of the lower limbs; bioengineering; biomechanical properties; aneurysmal dilatation; vascular trauma; arterial reconstruction; by-pass; angioplasty; aneurysmal rupture; adventitial collagen; photochemical crosslinking; mechanical reinforcement; proteolytic resistance; designing therapeutic strategies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to fill the knowledge gap in our understanding of the molecular mechanisms responsible for the tissue repair process and local remodeling after acute thromboembolic events such as myocardial infarction, stroke or acute limb ischemia.

The balance between pro- and anti-inflammatory immune mechanisms has a determining role in the severity of acute events and in the subsequent evolution of the patient. An excessive immune response in the acute period or an extended chronic inflammatory response during the recovery period can aggravate the initial injury and lead to defective tissue repair, with deleterious consequences for organ function and patient outcomes.

This Special Issue aims to publish a series of relevant papers presenting the most important current advances in understanding the molecular pathways involved in post-ischemic tissue repair and recovery. We also encourage colleagues to submit papers identifying new prognostic biomarkers and new therapies aiming to improve patient outcome. We welcome researchers to contribute manuscripts focusing on the molecular pathology, diagnostic methods, prognostic markers, as well as novel therapeutics addressing the repair process following an acute ischemic event.

Dr. Emil Marian Arbănași
Dr. Alexandru Schiopu
Dr. Eliza Russu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • pathogenic mechanisms
  • genetics cardiomyopathy
  • myocardial infarction
  • cardiac fibrosis
  • pharmacogenomics
  • drug discovery

Published Papers (2 papers)

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Research

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19 pages, 4291 KiB  
Article
Novel Fibrillar and Non-Fibrillar Collagens Involved in Fibrotic Scar Formation after Myocardial Infarction
by María Ortega, Maria Mar Fábrega-García, Tamara Molina-García, Jose Gavara, Elena de Dios, Nerea Pérez-Solé, Víctor Marcos-Garcés, Jaime José Padilla-Esquivel, Ana Diaz, Luis Martinez-Dolz, Manuel Jimenez-Navarro, Cesar Rios-Navarro, Vicente Bodí and Amparo Ruiz-Saurí
Int. J. Mol. Sci. 2024, 25(12), 6625; https://doi.org/10.3390/ijms25126625 - 16 Jun 2024
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Abstract
Following myocardial infarction (MI), adverse remodeling depends on the proper formation of fibrotic scars, composed of type I and III collagen. Our objective was to pinpoint the participation of previously unreported collagens in post-infarction cardiac fibrosis. Gene (qRT-PCR) and protein (immunohistochemistry followed by [...] Read more.
Following myocardial infarction (MI), adverse remodeling depends on the proper formation of fibrotic scars, composed of type I and III collagen. Our objective was to pinpoint the participation of previously unreported collagens in post-infarction cardiac fibrosis. Gene (qRT-PCR) and protein (immunohistochemistry followed by morphometric analysis) expression of fibrillar (types II and XI) and non-fibrillar (types VIII and XII) collagens were determined in RNA-sequencing data from 92 mice undergoing myocardial ischemia; mice submitted to permanent (non-reperfused MI, n = 8) or transient (reperfused MI, n = 8) coronary occlusion; and eight autopsies from chronic MI patients. In the RNA-sequencing analysis of mice undergoing myocardial ischemia, increased transcriptomic expression of collagen types II, VIII, XI, and XII was reported within the first week, a tendency that persisted 21 days afterwards. In reperfused and non-reperfused experimental MI models, their gene expression was heightened 21 days post-MI induction and positively correlated with infarct size. In chronic MI patients, immunohistochemistry analysis demonstrated their presence in fibrotic scars. Functional analysis indicated that these subunits probably confer tensile strength and ensure the cohesion of interstitial components. Our data reveal that novel collagens are present in the infarcted myocardium. These data could lay the groundwork for unraveling post-MI fibrotic scar composition, which could ultimately influence patient survivorship. Full article
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Review

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22 pages, 4378 KiB  
Review
Deciphering the Role of microRNAs: Unveiling Clinical Biomarkers and Therapeutic Avenues in Atrial Fibrillation and Associated Stroke—A Systematic Review
by Elke Boxhammer, Christiane Dienhart, Richard Rezar, Uta C. Hoppe and Michael Lichtenauer
Int. J. Mol. Sci. 2024, 25(10), 5568; https://doi.org/10.3390/ijms25105568 - 20 May 2024
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Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by binding to target messenger RNAs (mRNAs). miRNAs have been implicated in a variety of cardiovascular and neurological diseases, such as myocardial infarction, cardiomyopathies of various geneses, rhythmological diseases, neurodegenerative illnesses and [...] Read more.
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by binding to target messenger RNAs (mRNAs). miRNAs have been implicated in a variety of cardiovascular and neurological diseases, such as myocardial infarction, cardiomyopathies of various geneses, rhythmological diseases, neurodegenerative illnesses and strokes. Numerous studies have focused on the expression of miRNA patterns with respect to atrial fibrillation (AF) or acute ischemic stroke (AIS) However, only a few studies have addressed the expression pattern of miRNAs in patients with AF and AIS in order to provide not only preventive information but also to identify therapeutic potentials. Therefore, the aim of this review is to summarize 18 existing manuscripts that have dealt with this combined topic of AF and associated AIS in detail and to shed light on the most frequently mentioned miRNAs-1, -19, -21, -145 and -146 with regard to their molecular mechanisms and targets on both the heart and the brain. From this, possible diagnostic and therapeutic consequences for the future could be derived. Full article
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