The Immunology of Hepatitis B Infection
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2651
Special Issue Editors
Interests: HLA; GWAS; WGS, KIR, LILRA, COVID-19, hepatitis-B, SNPs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic hepatitis B and C account for 80% of all hepatocellular carcinoma (HCC) and most often occur in people with chronic liver diseases such as cirrhosis caused by hepatitis B or C. Hepatitis B virus (HBV) was first identified by Dr. Baruch Blumberg in 1965, and blood banks started to screen blood donations for hepatitis B in 1971. In 1975, the first heat-inactivated hepatitis B vaccine was developed by Dr. Blumberg and Dr. Irving Millman. HBV is a small, double-stranded DNA virus, and the serologic markers used to detect HBV infection include hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), immunoglobulin class G (IgG), immunoglobulin class M (IgM) antibodies to hepatitis B core antigen (IgM anti-HBc), and anti-HBc (IgG anti-HBc). Each of these markers represents the different phases of the viral infection. Genome-wide association studies of HBV-infected patients have identified several genetic markers such as HLA genes. These markers are useful in identifying patients who are prone to hepatitis B infection and patients at high risk of HCC progression and responses to hepatitis B vaccines. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: host genetic markers, viral genetic markers, hepatitis B vaccine efficacy, side effects of hepatitis B vaccination, hepatitis B viral strain variants, the immunology of hepatitis B infection, and population-based genome-wide association studies.
I look forward to receiving your contributions.
Dr. Seik-Soon Khor
Prof. Dr. Katsushi Tokunaga
Guest Editors
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Keywords
- hepatitis B
- HBV
- hepatocellular carcinoma
- HLA
- genetic markers
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