Inflammation versus Resolution: New Insights and Therapeutic Challenges in Atherosclerosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5172
Special Issue Editors
2. Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy
Interests: immunology; immundeficiencies; tumors; chemokine receptors; signaling
Special Issues, Collections and Topics in MDPI journals
2. Humanitas Clinical and Research Center – IRCCS, Rozzano, Italy
Interests: immunology; tumors; macrophages
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Atherosclerosis is a leading cause of morbidity and mortality in the Western world. It is a lipid-driven inflammatory disease of the arterial intima in which the balance between pro-inflammatory and inflammation-resolving mechanisms dictates the final clinical outcome. In its pathogenesis, endothelial cell damage causes the accumulation of oxidized low-density lipoproteins and exposes proteoglycans, thus inducing the synthesis of chemotactic and adhesion molecules that promote the recruitment of inflammatory cells in the intima. Activated leukocytes stimulate a cascade of reactions that is normally counterbalanced by body defense mechanisms, resolving or stabilizing the lesion with the help of endogenous mediators—so-called SPMs (specialized pro-resolving mediators). Nevertheless, if the inflammatory response is not well tackled, an imbalance in the ratio between SPM and pro-inflammatory lipids leads to plaque progression and vulnerability to rupture and thrombosis.
This Special Issue is aimed to collect original research and review articles on genetic, molecular, and cellular mechanisms that are recognized as key players in inflammation and resolution, and which might represent valid targets of new therapeutic challenges for the treatment of atherosclerosis.
Prof. Dr. Elena Monica Borroni
Dr. Benedetta Savino
Guest Editors
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