Protein Kinases and Pseudokinases in Cancer and the Tumour Microenvironment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 2579
Special Issue Editors
Interests: cancer; tumour microenvironment; signal transduction; kinases; pseudokinases; fibroblasts; immune cells
Special Issues, Collections and Topics in MDPI journals
Interests: development; cancer; chemotherapy; metastasis; programmed cell death; metabolism; Drosophila aging; brain signaling; proteasome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to announce the special issue: “Protein Kinases and Pseudokinases in Cancer and the Tumour Microenvironment”.
Protein kinases have a central role in cancer development and progression and represent excellent therapeutic targets. From early research to novel members of the human kinome, understanding of their contribution to diseases including cancer is growing every day. Moreover, it is also well-established that protein kinases play an important part in signalling within the tumour microenvironment.
Similar to their catalytically active counterparts, psuedokinases are essential component of the human kinome. With their unique structural features, the role of pseudokinases in a number of physiological processes and in human diseases has become increasingly apparent. Yet, members of the ‘pseudokinome’ remain largely unexplored.
This Special Issue aims to collect high-quality publications on the role of kinases and pseudokinases in both the development of cancer and their contribution within the tumour microenvironment. Original research papers and updated review articles are invited on topics including but not limited to: kinase and pseudokinase signalling in cancer initiation and progression and how these may be targeted in cancer treatments. Papers discussing the role of protein kinases in the tumour microenvironment and their involvment in interplay between the microenvrionment (eg. immune cells, fibroblasts, astrocytes, neuronal cells, etc) and cancer cells are also welcomed.
Prof. Dr. Georgios Giamas
Dr. Dimitrios J. Stravopodis
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- tumour microenvironment
- signal transduction
- kinases
- pseudokinases
- fibroblasts
- immune cells
- targeted therapy
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