Cancer Models: Development and Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 10
Special Issue Editor
Interests: metastasis; molecular pathway; cancer models; metabolism; tumor microenvironment; drug screening and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Success rates for therapeutics in clinical development remain low, largely due to the lack of appropriate and efficient in vitro and in vivo models that accurately reflect the complexity of human disease. Without such models, it is difficult to develop promising drug candidates or to fully understand the fundamental mechanisms underlying disease progression and treatment response. Cancer models, in particular, play a critical role in studying cancer biology, disease progression, and therapeutic intervention in a controlled setting. These models allow researchers to explore the molecular and cellular aspects of cancer, identify potential drug targets, and test the efficacy of new therapies before moving them into clinical trials. In recent years, significant advances have been made in the development of preclinical cancer models. These include innovative systems such as perfused 3D organoids, which mimic the tumor microenvironment and allow for more physiologically relevant drug testing, and patient-derived xenografts (PDX), in which human tumor tissue is implanted into immunocompromised mice to closely mimic the characteristics of the original patient's cancer. Genetically engineered mouse models (GEMMs) are also widely used to study the role of specific genes in tumor development and response to therapy. In addition, zebrafish cancer models have emerged as a powerful tool for high-throughput screening due to their rapid development and genetic similarity to humans. Each of these models has unique strengths and limitations. By using a combination of these complementary models, researchers can better understand cancer mechanisms, more effectively evaluate therapeutic candidates, and move closer to developing personalized cancer treatments.
We kindly invite you to contribute to this Special Issue with original research articles or comprehensive reviews on all aspects related to the theme of "Cancer Models: Development and Applications". Please note that short perspective papers or purely clinical studies cannot be considered. The goal of this Special Issue is to advance our understanding of the progress in the field of cancer models and to explore how these models can be better leveraged to translate basic research into clinical breakthroughs.
Dr. Yong Teng
Guest Editor
Manuscript Submission Information
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Keywords
- tumor organoids
- animal models of cancer
- drug screening models
- highly clinically relevant cancer models
- technologies related to cancer model development
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