Regulation and Targeting of Ferroptosis in Tumor and Beyond (Second Edition)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 143
Special Issue Editor
Interests: metastasis; molecular pathway; cancer models; metabolism; tumor microenvironment; drug screening and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ferroptosis is a newly emerged programmed necrosis process implicated in multiple biological and pathological conditions. As a novel form of regulated cell death (RCD), ferroptosis has garnered increasing attention in studies on numerous human diseases in the last decade. Numerous cellular factors and potential regulatory pathways underlying ferroptosis have been elucidated; however, its precise mechanism and function are not well understood. Emerging evidence has demonstrated that ferroptosis is an iron-dependent form of nonapoptotic cell death induced by excessive lipid peroxidation, which is accompanied by an increased uptake of polyunsaturated fatty acids into the cellular membrane and further unfolding an ancient vulnerability in multiple contexts. Ferroptosis susceptibility has been demonstrated in many cancers, including hepatocellular carcinoma, breast cancer, and head and neck cancer. Ferroptosis induction, a nonapoptotic, regulated cell death modality, is a promising anti-cancer strategy.
The main aim of this topic is to study the mechanistic underpinnings of ferroptosis. Those include how ferroptosis is regulated at the molecular level and how to target its pathways therapeutically. Here, we will pay extra attention to these articles about novel/non-canonical ferroptosis pathways. This SI aims to advance our understanding of the fundamental biological process of ferroptosis and potentially identify new approaches to manipulate it for therapeutic benefits. Original research articles, reviews, and mini-reviews are welcome to be submitted to this research topic. Papers are expected to cover but are not limited to the following topics:
- Basic mechanisms involved in ferroptosis and critical regulators of ferroptosis.
- The role of proto-oncogenes and tumor suppressor genes in canonical and non-canonical ferroptosis regulation.
- Targeting ferroptosis for disease treatment.
- Ferroptosis and immunotherapy.
- Ferroptosis and cellular metabolism.
- Studies related to other cell death mechanisms (including but not limited to pyroptosis, apoptosis, necroptosis, and PANoptosis).
- The role of ferroptosis in drug resistance and stem cells.
- New drugs and targeting therapeutics associated with ferroptosis.
Dr. Yong Teng
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ferroptosis
- iron
- tumor survival and cell death
- oxidation
- drug development
- anti-cancer strategies
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
