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Molecular Insights into Atherosclerosis and Vascular Endothelial Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 2320

Special Issue Editor


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Guest Editor
Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji 192-0392, Japan
Interests: reactive oxygen species; oxidative stress; shear stress; inflammation; adhesion molecule; vascular permeability; vascular morphology; vascular toxicity; apoptosis; vascular disease; atherosclerosis; proliferation; migration; metallothionein
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Special Issue Information

Dear Colleagues,

Atherosclerosis is a major cause of many cardiovascular diseases, and its etiology and mechanisms are rather complex. However, as evident from previous research, dysfunction of vascular endothelial cells is generally recognized as the starting point.

In this Special Issue, we welcome submissions of recent reviews, original papers, short communications, as well as perspectives that provide a clarification of the underlying mechanisms determining the onset, progression, and complications of atherosclerosis, thereby leading to the development of future therapeutic approaches and preventive strategies.

Potential topics related to vascular endothelial cell research include the following:

  • Inflammatory responses;
  • Oxidative stress;
  • Mechanical and rheological stress;
  • Regulation of blood coagulation-fibrinolysis system;
  • Cell–cell interactions;
  • Cell–extracellular matrix interactions;
  • Novel risk factors and other significant contributors

Dr. Takato Hara (from Toho University, Japan) is a good scientist serving as the Topical Advisory Panel in IJMS, who will assist Prof. Fujiwara in managing this Special Issue.

Prof. Dr. Yasuyuki Fujiwara
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (2 papers)

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Research

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8 pages, 514 KiB  
Communication
A Potential Link between Myeloperoxidase Modified LDL, Atherosclerosis and Depression
by Jalil Daher
Int. J. Mol. Sci. 2024, 25(16), 8805; https://doi.org/10.3390/ijms25168805 - 13 Aug 2024
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Abstract
Atherosclerosis is a chronic inflammatory disease that involves modified low-density lipoproteins (LDL) which play a pivotal role in the initiation and progression of the disease. Myeloperoxidase oxidized LDL (Mox-LDL) is considered to be the most patho-physiologically relevant type of modified LDL and has [...] Read more.
Atherosclerosis is a chronic inflammatory disease that involves modified low-density lipoproteins (LDL) which play a pivotal role in the initiation and progression of the disease. Myeloperoxidase oxidized LDL (Mox-LDL) is considered to be the most patho-physiologically relevant type of modified LDL and has been reported to be ubiquitously present in atheroma plaques of patients with atherosclerosis. Besides its involvement in the latter disease state, Mox-LDL has also been shown to be implicated in the pathogenesis of various illnesses including sleep disorders, which are in turn associated with heart disease and depression in many intricate ways. Meanwhile, we have recently shown that lox-1-mediated Mox-LDL signaling modulates neuroserpin activity in endothelial cells, which could have major implications that go beyond the pathophysiology of stroke and cerebrovascular disease (CD). Of note is that tissue plasminogen activator (tPA), which is the main target of neuroserpin in the brain, has a crucial function in the processing of brain-derived neurotrophic factor (BDNF) into its mature form. This factor is known to be involved in major depressive disorder (MDD) development and pathogenesis. Since tPA is more conventionally recognized as being involved in fibrinolytic mechanisms, and its effect on the BDNF system in the context of MDD is still not extensively studied, we speculate that any Mox-LDL-driven change in the activity of tPA in patients with atherosclerosis may lead to a decrease in the production of mature BDNF, resulting in impaired neural plasticity and depression. Deciphering the mechanisms of interaction between those factors could help in better understanding the potentially overlapping pathological mechanisms that regulate disease processes in CD and MDD, supporting the possibility of novel and common therapeutic opportunities for millions of patients worldwide. Full article
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Review

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16 pages, 2250 KiB  
Review
Molecular Mechanisms Regulating Vascular Endothelial Permeability
by Rio Wakasugi, Kenji Suzuki and Takako Kaneko-Kawano
Int. J. Mol. Sci. 2024, 25(12), 6415; https://doi.org/10.3390/ijms25126415 - 11 Jun 2024
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Abstract
Vascular endothelial cells form a monolayer in the vascular lumen and act as a selective barrier to control the permeability between blood and tissues. To maintain homeostasis, the endothelial barrier function must be strictly integrated. During acute inflammation, vascular permeability temporarily increases, allowing [...] Read more.
Vascular endothelial cells form a monolayer in the vascular lumen and act as a selective barrier to control the permeability between blood and tissues. To maintain homeostasis, the endothelial barrier function must be strictly integrated. During acute inflammation, vascular permeability temporarily increases, allowing intravascular fluid, cells, and other components to permeate tissues. Moreover, it has been suggested that the dysregulation of endothelial cell permeability may cause several diseases, including edema, cancer, and atherosclerosis. Here, we reviewed the molecular mechanisms by which endothelial cells regulate the barrier function and physiological permeability. Full article
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