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Immune System and Immune Responses in Fish and Their Role in Comparative Immunity Study

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1607

Special Issue Editor


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Guest Editor
1. Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China
2. Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Interests: fish immunology; virus; AMPs; toxicology; cell lines; vaccines; aquaculture; biotechnology

Special Issue Information

Dear Colleagues,

The immune system of fish is relatively weak and simple compared to that of mammals because of evolution. It is helpful to study fish immunology to fully understand the immunity mechanisms. The molecular mechanisms of fish immunology have been a focus in the recent years; therefore, this Special Issue focuses on the molecular mechanisms of fish immunology in disease challenges, environment stress, innate immunity, and adaptive immunity, to reveal the crosstalk between disease and immunity, to discover and identify key genes as well as interacting proteins, and to elucidate the signal transduction pathway. It also welcomes studies on fish vaccine and gene editing technology with which to regulate immunity and improve disease resistance. The animals include, but are not limited to, freshwater fish, marine fish, shrimp, shellfish, etc. Current studies in this field aiming to reveal the difference in mechanisms of fish and mammals are welcome too.

This Special Issue, “Immune System and Immune Responses in Fish and Their Role in Comparative Immunity Study”, welcomes original research and review papers considering biological process analyses of important nutrients, immune gene cloning and functional identification, the molecular mechanisms of nutrient-enhancing immunity, and all other related processes. Papers detailing bioinformatic tools and databases used for the intestinal immunologic barrier and immunostimulants are also welcomed.

Dr. Qunlan Zhou
Guest Editor

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Keywords

  • innate immunity
  • adaptive immunity
  • antioxidant capacity
  • inflammation
  • intestinal immunologic barrier
  • vaccine
  • gene editor

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Published Papers (1 paper)

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Research

24 pages, 6241 KiB  
Article
Discovery and Characterization of the ddx41 Gene in Atlantic Salmon: Evolutionary Implications, Structural Functions, and Innate Immune Responses to Piscirickettsia salmonis and Renibacterium salmoninarum Infections
by Alejandro J. Yañez, Claudia A. Barrientos, Adolfo Isla, Marcelo Aguilar, Sandra N. Flores-Martin, Yassef Yuivar, Adriana Ojeda, Pablo Ibieta, Mauricio Hernández, Jaime Figueroa, Rubén Avendaño-Herrera and Marcos Mancilla
Int. J. Mol. Sci. 2024, 25(12), 6346; https://doi.org/10.3390/ijms25126346 - 8 Jun 2024
Cited by 1 | Viewed by 1306
Abstract
The innate immune response in Salmo salar, mediated by pattern recognition receptors (PRRs), is crucial for defending against pathogens. This study examined DDX41 protein functions as a cytosolic/nuclear sensor for cyclic dinucleotides, RNA, and DNA from invasive intracellular bacteria. The investigation determined [...] Read more.
The innate immune response in Salmo salar, mediated by pattern recognition receptors (PRRs), is crucial for defending against pathogens. This study examined DDX41 protein functions as a cytosolic/nuclear sensor for cyclic dinucleotides, RNA, and DNA from invasive intracellular bacteria. The investigation determined the existence, conservation, and functional expression of the ddx41 gene in S. salar. In silico predictions and experimental validations identified a single ddx41 gene on chromosome 5 in S. salar, showing 83.92% homology with its human counterpart. Transcriptomic analysis in salmon head kidney confirmed gene transcriptional integrity. Proteomic identification through mass spectrometry characterized three unique peptides with 99.99% statistical confidence. Phylogenetic analysis demonstrated significant evolutionary conservation across species. Functional gene expression analysis in SHK-1 cells infected by Piscirickettsia salmonis and Renibacterium salmoninarum indicated significant upregulation of DDX41, correlated with increased proinflammatory cytokine levels and activation of irf3 and interferon signaling pathways. In vivo studies corroborated DDX41 activation in immune responses, particularly when S. salar was challenged with P. salmonis, underscoring its potential in enhancing disease resistance. This is the first study to identify the DDX41 pathway as a key component in S. salar innate immune response to invading pathogens, establishing a basis for future research in salmonid disease resistance. Full article
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