Advances in Melanoma and Skin Cancers: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 29
Special Issue Editors
Interests: oncology; translational research of skin cancers; identification of prognostic or predictive biomarkers for immunotherapy treatment; study of gene expression profile in patients with skin cancer; analysis of resistance mechanisms of immunotherapy treatment; biochemical and immunological monitoring; study of immunotherapy treatments in solid tumors; combination strategies with I-O
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; Immunotherapy; melanoma
Interests: skin cancers; immunotherapy; melanoma; solid tumors; immune mechanisms from Sars-CoV-2 infection in cancer patients
Special Issue Information
Dear Colleagues,
Malignant melanoma is the most aggressive skin cancer, with a high potential for relapse and metastasization. Treatment with classic chemotherapy drugs has a response rate of 10% and a short survival. The availability of immune checkpoint inhibitors (ICIs) has radically changed the prognosis not only in melanoma but also in the majority of skin cancers. Indeed, immunotherapy is currently considered the standard of care as an adjuvant therapy in high-risk resected stage III or IV melanoma, and it also demonstrates excellent results in other skin cancers. Despite these important advances, a large subgroup of patients do not respond to treatment, or relapse due to the onset of primary or acquired resistance, resulting in treatment failure in approximately 50% of patients. Therefore, it is necessary to identify specific biomarkers capable of predicting the clinical benefit of immunotherapy in melanoma and skin cancer patients.
The purpose of this Special Issue is to report the resistance mechanisms and prognostic/predictive molecular markers of immunotherapy treatment in patients with skin cancers. Original research, reviews, and short communication articles mainly focusing on the molecular basis of and advances in skin cancer immunotherapy are welcome.
Dr. Domenico Mallardo
Dr. Debora Basile
Dr. Maria Grazia Vitale
Guest Editors
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Keywords
- melanoma
- immunotherapy
- biomarkers
- translational research
- drug repurposing
- clinical outcome
- prognostic markers
- predictive markers
- combination immunotherapy
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