Cellular and Molecular Biology of Heart Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 4126
Special Issue Editor
Interests: molecular mechanism of hereditary cardiomyopathies; protein structure-function relationships; hypertrophic cardiomyopathy; signalling pathways; cell-cell communication via exosomes; post-translational modifications
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Special Issue Information
Dear Colleagues,
Cardiomyopathies are a heterogeneous group of heart muscle diseases with several different phenotypes. They can be classified into inherited and acquired forms, the pathomechanisms of which are the focus of this Special Issue. In cardiomyopathies, either the cardiac muscle cells may be primarily affected or the heart may be the target of various systemic diseases. There is still a large gap in our understanding of the molecular mechanisms of disease development. This missing knowledge is a huge obstacle to the development of specific therapies, especially for the early stage of disease, enabling the inhibition of disease progression.
Inherited and acquired cardiomyopathies are characterized by extensive pathological remodeling of the heart and its cardiomyocytes. Intact structure and intracellular microdomains, the smooth operation of signaling networks, and intercellular communications are essential for the function of cardiomyocytes. Disturbances in these processes and in structural integrity lead to contractile and electrical dysfunction, progressing to heart diseases. In this Special Issue, we intend to cover alterations that may occur in cardiomyopathies. We ask authors to submit papers that provide an improved understanding of Ca2+ homoeostasis, protein–protein interactions, post-translational modifications of proteins, the protein quality control system, inflammation processes, mechanosensing, trafficking/communication between cell compartments and between cells, signaling pathways, protein expression and its regulation, and how these factors contribute to the development of disease. As for model systems, we welcome in vitro systems, isolated cardiomyocytes, iPS cells, and tissue or animal models, each having specific limitations and advantages.
Therefore, we especially welcome submissions of original studies that cover one of these topics, but reviews will also be considered.
Dr. Heidi Budde ([email protected]), whose central area of research interest is heart disease, is serving as the Co-Guest Editor and will assist Prof. Dr. Kornelia Jaquet in managing this Special Issue.
Prof. Dr. Kornelia E. Jaquet
Guest Editor
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Keywords
- cellular biology
- heart disease
- cardiomyopathy
- pathomechanisms
- contractility
- signaling
- protein interaction
- post-translational modification
- pathogenic mutation
- gene expression
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