Embryonic Development and Differentiation

Dear Colleagues,

Human infertility is a global problem with significant social and economic impact. Successful pregnancy is a complex process that comprises unique events, including fertilization, implantation, decidualization, placentation, and finally birth. Nowadays, the assisted reproduction technologies (ART) have provided a remarkable impact for successful pregnancy after in vitro fertilization. However, these methods are associated with a relatively low clinical pregnancy rate of approximately 30% per transfer. The receptive phase of uterus is marked by structural and functional maturation of endometrium. This is a limited time span when the blastocyst competency is superimposed on the receptive endometrium. It is a well-known fact that the lipid and protein metabolism and signaling of early stage pregnancy are of a vital importance in successful embryogenesis. However, the embryo-maternal molecular communication is not well understood, nor it is understood whether the low take-home baby outcome of IVF is the result of some abnormal molecular networking.

This Special Issue is calling for both original articles and reviews that will provide the readers of IJMS a comprehensive elucidation of fertilization, embryonic development, as well as the molecular networking during embryogenesis.

Dr. Laszlo Mark
Guest Editor

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