Lipid Metabolism in Cancer as a Source of Biomarkers and Therapeutical Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 7880
Special Issue Editors
Interests: membrane lipidome; imaging mass spectrometry; inflammatory bowel disease; colorectal cancer; lipid fingerprint; lipid biomarkers; lipid pharmacological targets
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advances in lipidomic and metabolomic techniques have placed lipids in a crucial spot in the field of biomedicine.
On the one hand, it is well known that malignant cells reshape their biosynthetic and bioenergetic requirements to be able to cope with the specific demands associated with the formation and maintenance of the cancer process. In addition to providing energy, the enhancement of lipid uptake and the sustained activation of the de novo lipogenesis make cancer cells the membrane building blocks needed to support rapid proliferation, as well as a repertoire of lipid signaling molecules.
On the other hand, the development of imaging mass spectrometry techniques has helped to demonstrate beyond doubt that the cell lipid profile is cell type-dependent. Even more, cell lipidome has turned out to be highly sensitive to pathophysiological alterations, such as differentiation or tumorigenesis.
However, the regulatory mechanisms that finely control the levels and fate of each one of the lipid species detected remain largely unknown, which make it complicated to infer the biological impact of the results. In this context, the combination of “-omic” techniques, particularly using system biology approaches, could provide new hints to understand the complex networks underlying the control of lipid metabolism. Altogether, the study of lipid metabolism offers a unique opportunity to identify new therapeutic targets and novel specific biomarkers for cancer.
This Special Issue aims to highlight the research and strategies currently used to identify lipid biomarkers for cancer diagnosis, prognosis and treatment monitoring. It also welcomes all those studies seeking to elucidate new regulatory pathways of the lipidome and their role in tumorigenesis and cancer progression by combining different “omic” techniques.
Dr. Gwendolyn Barceló-Coblijn
Dr. Alice Chaplin
Guest Editors
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Keywords
- membrane lipid metabolism
- lipidomics
- transcriptomics
- genomics
- proteomics
- system biology
- imaging mass spectrometry
- tumorigenesis
- differentiation
- stem cells
- cancer risk factors
- cancer
- lipid biomarkers
- lipid pharmacological targets
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