Melanosome Transport/Transfer and Melanin Pigmentation in the Skin 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 15194
Special Issue Editors
Interests: melanin; melanosomes; melanocytes; keratinocytes; melanoma
Interests: melanin; melanocyte; melanosome; pigmentation; tyrosinase; ultraviolet light
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Melanin pigments are produced by melanocytes located in the basal layer of the epidermis and transferred to keratinocytes. Melanin pigments are synthesized in specialized organelles within melanocytes, termed melanosomes. Melanosomes move along the cytoskeleton to the dendrites of melanocytes and are then transferred to surrounding keratinocytes, where they are processed and accumulate over the nucleus, forming supra-nuclear caps. Defective melanosome trafficking results in hyper- and hypo-pigmentary disorders such as melasma, age spots, Hermansky–Pudlak/Griscelli/Chediak–Higashi syndromes and vitiligo. Many studies have characterized the mechanisms of melanosome biogenesis and transport in melanocytes, but fewer have addressed the mechanisms of melanosome transfer to keratinocytes and further processing within these cells. Therefore, many unknown mechanisms remain to be clarified. Through the elucidation of these mechanisms, the development of novel therapeutic agents for pigmentary disorders is expected. In this Special Issue, reviews and original articles related to melanosome transport/transfer and melanin pigmentation, as well as research topics on the degradation/processing and polarization of melanin within keratinocytes, are welcome.
Dr. Duarte C. Barral
Prof. Dr. Hideya Ando
Guest Editors
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Keywords
- endocytosis
- exocytosis
- fibroblast
- keratinocyte
- melanin
- melanocyte
- melanosome
- pigmentation
- trafficking
- transfer
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