Multiple Enzyme Mechanism and Functions in Mitochondrial Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 10964
Special Issue Editors
Interests: Mitochondrial enzymes; mitochondrial biogenesis; mitochondrial metabolism
Interests: mitochondria; bioenergetics; ATP synthase; permeability transition pore; mitochondrial supercomplexes; cell metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are dynamic and signalling organelles that regulate a wide variety of cellular functions and can dictate cell fate. They house the major enzymatic systems used to complete the oxidation of sugars, fats and proteins to produce ATP, but they play a vital role also in biosynthetic pathways and can rapidly adjust to meet the metabolic needs of the cell. Important byproducts of mitochondrial electron transport are reactive oxygen species which at low levels can act in cell signalling pathways. These radicals are balanced by strong mitochondrial antioxidant defence systems to prevent oxidative damage. Mitochondria are also involved in regulated cell death through activation of the mitochondrial permeability transition pore. Mitochondrial dynamics, which include mitochondrial fission, fusion and biogenesis, governs mitochondrial function and localization within the cell. All these processes involve the correct functioning of many enzymes whose activity is often regulated by post-translational modifications and mitochondrial dysfunctions can therefore also lead to various diseases. Knowledge of the enzyme mechanisms and regulation can therefore play an important role also in the identification of new pharmacological therapies.
In this Special Issue, we encourage the submission of manuscripts that improve and update knowledge in mitochondrial function and related enzyme mechanism to deepen their role in health and disease and reveal novel mitochondria-targeting therapeutic opportunities. Topical reviews on these topics are also welcome.
Dr. Fabiana Trombetti
Dr. Salvatore Nesci
Guest Editors
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Keywords
- Mitochondrial enzymes
- mitochondrial biogenesis
- mitochondrial metabolism
- mitochondrial respiration
- mitochondrial permeability transition
- mitochondrial cell death and diseases
- mitochondrial ROS
- mitochondria-targeted therapy
- drug discovery
- ATP synthase
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