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Molecular Diagnostics and Treatment of Inflammatory Bowel Disease

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Guest Editor
Internal Medicine and Gastroenterology Department, IRCCS Fondazione Policlinico Gemelli, Catholic University of Rome, 00168 Rome, Italy
Interests: inflammatory bowel disease (IBD); target therapy; mucosal immunology; inflammatory cytokines; gut microbiota; intestinal mucosal healing; IBD murine models; tumorigenesis associated to chronic inflammation
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Special Issue Information

Dear Colleagues,

In recent years, many advances in the pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, have emerged with a substantial impact on daily clinical practice. These new findings allowed for the introduction of new molecular markers and innovative drugs useful for an innovative clinical approach to IBD. We propose to your attention a Special Issue of IJMS including reviews and research articles regarding recent advances in the field of basic and molecular research with translational applications in IBD.

The establishment of new goals in the management of IBD and the continuation of the understanding of the pathogenic mechanisms of IBD have introduced new concepts in the areas of intestinal fibrogenesis, small oral therapeutic molecules, gut microbiota, molecular markers of intestinal healing, and molecular predictive markers of response to therapy.

In this Special Issue, we will welcome your contributions in the form of original research and review articles facing each side of basic, molecular, and translational research in IBD.

Prof. Dr. Loris Riccardo Lopetuso
Guest Editor

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Keywords

  • IBD molecular pathogenesis
  • intestinal mucosal healing
  • gut microbiota in IBD
  • fecal microbiota transplantation
  • target therapy in IBD
  • stem cell therapy
  • biologic agents
  • small molecules
  • adhesion antagonists
  • inflammatory cytokines
  • lymphocyte control

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Published Papers (1 paper)

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Research

21 pages, 3389 KiB  
Article
A Novel Microbial Dysbiosis Index and Intestinal Microbiota-Associated Markers as Tools of Precision Medicine in Inflammatory Bowel Disease Paediatric Patients
by Francesca Toto, Chiara Marangelo, Matteo Scanu, Paola De Angelis, Sara Isoldi, Maria Teresa Abreu, Salvatore Cucchiara, Laura Stronati, Federica Del Chierico and Lorenza Putignani
Int. J. Mol. Sci. 2024, 25(17), 9618; https://doi.org/10.3390/ijms25179618 - 5 Sep 2024
Cited by 2 | Viewed by 2375
Abstract
Recent evidence indicates that the gut microbiota (GM) has a significant impact on the inflammatory bowel disease (IBD) progression. Our aim was to investigate the GM profiles, the Microbial Dysbiosis Index (MDI) and the intestinal microbiota-associated markers in relation to IBD clinical characteristics [...] Read more.
Recent evidence indicates that the gut microbiota (GM) has a significant impact on the inflammatory bowel disease (IBD) progression. Our aim was to investigate the GM profiles, the Microbial Dysbiosis Index (MDI) and the intestinal microbiota-associated markers in relation to IBD clinical characteristics and disease state. We performed 16S rRNA metataxonomy on both stools and ileal biopsies, metabolic dysbiosis tests on urine and intestinal permeability and mucosal immunity activation tests on the stools of 35 IBD paediatric patients. On the GM profile, we assigned the MDI to each patient. In the statistical analyses, the MDI was correlated with clinical parameters and intestinal microbial-associated markers. In IBD patients with high MDI, Gemellaceae and Enterobacteriaceae were increased in stools, and Fusobacterium, Haemophilus and Veillonella were increased in ileal biopsies. Ruminococcaceae and WAL_1855D were enriched in active disease condition; the last one was also positively correlated to MDI. Furthermore, the MDI results correlated with PUCAI and Matts scores in ulcerative colitis patients (UC). Finally, in our patients, we detected metabolic dysbiosis, intestinal permeability and mucosal immunity activation. In conclusion, the MDI showed a strong association with both severity and activity of IBD and a positive correlation with clinical scores, especially in UC. Thus, this evidence could be a useful tool for the diagnosis and prognosis of IBD. Full article
(This article belongs to the Special Issue Molecular Diagnostics and Treatment of Inflammatory Bowel Disease)
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