Ischemic Retinal Diseases: Pathophysiology, Retinal Imaging and Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (10 June 2024) | Viewed by 4959
Special Issue Editors
Interests: diabetic retinopathy; AMPA excitotoxicity; neurodegeneration; neuroinflammation; vasculopathy; neuroprotection; endocannabinoid system; NADPH oxidases
Interests: neuroprotection; physiology and pathology of the retina; physiology and pathology of the neurovascular unit; regulation of growth factor expression; nutraceuticals
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Special Issue Information
Dear Colleagues,
Retinal ischemia leads to excitotoxicity and oxidative stress. The production of excessive reactive oxygen/nitrogen species (ROS/RNS) contributes to the induction of neurodegeneration, neuroinflammation, vasculopathy, and severe neovascularization, thus playing a major role in the pathogenesis of retinal diseases, such as age-related macular degeneration, diabetic retinopathy, glaucoma, and retinopathy of prematurity. Current therapies treat only the advanced stages of chronic retinal diseases. Many investigations focus on the development of new therapeutics, antioxidants, neuroprotectants, anti-inflammatory and vasculoprotective agents. Further technological advances in retinal imaging for screening the early pathology of retinal diseases and its progression, as well as the discovery of new therapeutics, are essential in improving the eyesight and quality of life of patients, as well as hampering the growing public health burden of retinal diseases. The main aim of this special issue is to attract contributions of “state-of-the-art” therapeutic interventions for the early stage of diseases and thus delay their progress to the advanced pathological stage where the eyesight of patients is compromised. At another level, the aim is to welcome contributions of new advances in retinal imaging that could make an impact in screening, identifying early disease pathologies, and selecting the appropriate neuroprotective drugs for implementing personalized treatments.
Prof. Dr. Kyriaki Thermos
Dr. Giovanni Casini
Guest Editors
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Keywords
- retinal ischemia diseases
- excitotoxicity
- oxidative stress
- neurodegeneration
- neuroinflammation
- vasculopathy
- neuroprotection
- antioxidants
- age-related macular degeneration
- diabetic retinopathy
- glaucoma
- retinopathy of prematurity
- retinal imaging
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