Neuronal Voltage-Gated Channel Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 8132
Special Issue Editors
Interests: dendrites; intrinsic excitability; learning and memory; synaptic plasticity; hippocampus; ion channels; voltage-gated potassium channels; neuronal development; Autism
Interests: voltage-gated ion channels; calcium signaling; synaptic plasticity; fragile X syndrome; potassium channel interacting proteins; ion channel regulation by post transcriptional modifications
Special Issue Information
Dear Colleagues,
Neuronal voltage-gated ion channels (nVGICs) control neuronal excitability and plasticity. Regulation of ion channel function by post-translational modifications and/or channel-associated regulatory proteins affect their expression, biophysical properties, subcellular localization, trafficking, and subsequent intracellular signaling. Inherited mutations affecting nVGICs or their regulation produce channel-based pathologies or “channelopathies” that affect the central nervous system including epilepsy, Fragile X syndrome, ataxia, and pain syndromes. Dysregulation of nVGICs is also strongly associated with pathophysiology in central nervous system disorders affecting memory and mental illness. This special issue focusses on channel physiology with an emphasis on the diverse means by which nVGIC function is regulated. nVGICs are themselves frequent drug targets but greater understanding of their regulation may lead to new tool development providing a vital, more subtle resource for future therapeutics.
Dr. Dax A. Hoffman
Dr. Jonathan G. Murphy
Guest Editors
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Keywords
- voltage-gated ion channel
- post-translational modifications
- auxiliary subunits
- excitability
- ion channel regulation
- channelopathies
- tools for ion channel research
- ion channel pharmacology
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